Publication Name	World Journal of Hepatology
Manuscript ID	103217
Country	Germany

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	MANPOWER study: Real-world post-hoc analysis assessing essential phospholipids for non-alcoholic fatty liver disease from the Russian registry
Manuscript Source	Unsolicited Manuscript
All Author List	Asad Izziddin Dajani, Branko Popovic, Caroline Amand, Sabine Tong, Kirill Maximovich Starostin and Victor Goncharuk
Funding Agency and Grant Number
Corresponding Author	Branko Popovic, MD, Global Medical Affairs, A. Nattermann & Cie. GmbH, Aqua Tower, Junghofstraße 9, Frankfurt am Main 60315, Germany. branko.popovic@sanofi.com
Key Words	Algorithms; Essential phospholipids; Liver enzymes; Non-alcoholic fatty liver disease; Ultrasonography
Core Tip	Essentiale Forte N®, administered as adjunctive therapy in patients with non-alcoholic fatty liver disease (NAFLD), reduced liver enzyme levels [alanine transaminase (ALT), aspartate transaminase (AST) and gamma-glutamyl transferase (GGT)] and improved ultrasonographic features of NAFLD, particularly with regard to liver hyperechogenicity and structure, with a greater reduction noted with increasing NAFLD severity. These data indicate that Essentiale, alone or in combination with other treatment, is effective for the management of NAFLD. Additionally, a non-invasive diagnostic algorithm based on the statistical distribution of three liver enzymes (ALT, AST, and GGT) could be used to increase the accuracy of diagnosis, staging, and monitoring of patients with NAFLD.
Citation	Dajani AI, Popovic B, Amand C, Tong S, Starostin KM, Goncharuk V. MANPOWER study: Real-world post-hoc analysis assessing essential phospholipids for non-alcoholic fatty liver disease from the Russian registry. World J Hepatol 2025; In press

Received	2024-11-13 10:18
Peer-Review Started	2024-11-21 03:50
To Make the First Decision
Return for Revision	2025-01-10 03:23
Revised	2025-03-10 14:44
Second Decision	2025-05-19 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-21 12:30
Articles in Press	2025-05-21 12:30
Publication Fee Transferred	2025-03-19 10:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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