Publication Name	World Journal of Diabetes
Manuscript ID	103511
Country	China

Category	Urology & Nephrology
Manuscript Type	Basic Study
Article Title	Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism
Manuscript Source	Unsolicited Manuscript
All Author List	Zhong-Yong Zhang, Yu-Ming Wang, Ning Wang, Yuan-Song Wang, Hui Zhang, Duo Wang, Li-Xin Wang, Huan-Tian Cui, Wei-Bo Wen, Shu-Quan Lv and Yong-Jun Cao
Funding Agency and Grant Number	Funding Agency Grant Number the Natural Science Foundation of Hebei Province Beijing-Tianjin-Hebei Basic Research Special Program H2020110287 Key Laboratory for Diabetic Kidney Disease Syndrome and Treatment of the Traditional Chinese Medicine Administration of Hebei Province 7 [2024] Yuansong Wang National Famous Traditional Chinese Medicine Expert Heritage Studio 3 [2024] Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications SZX2020015 Jiangsu Province Chinese Medicine Science and Technology Development Program Project YB2020065
Corresponding Author	Shu-Quan Lv, Chief Physician, PhD, Department of Endocrinology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, No. 5 Xianghai Road, High-tech Zone, Cangzhou 061012, Hebei Province, China. czlvshuquan@163.com
Key Words	Diabetic nephropathy; Shenzhuo formulation; Transcriptomic; Metabolomic; Cytochrome P450; Arachidonic acid metabolic; Inflammatory; Oxidative stress
Core Tip	This study aimed to evaluate the therapeutic impact of Shenzhuo formulation (SZF) on a diabetic nephropathy (DN) mouse model and to examine its potential molecular mechanisms using transcriptomic and metabolomic approaches. The findings of this research substantiated the significant potential of SZF in ameliorating renal injury in DN mice. The primary pathway through which SZF mitigates renal injury appears to be the modulation of cytochrome P450-mediated AA metabolism, which contributes to its anti-inflammatory and antioxidant effects.
Citation	<p>Zhang ZY, Wang YM, Wang N, Wang YS, Zhang H, Wang D, Wang LX, Cui HT, Wen WB, Lv SQ, Cao YJ. Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism. <i>World J Diabetes</i> 2025; 16(5): 103511</p>

Received	2024-11-28 13:33
Peer-Review Started	2024-12-09 01:42
To Make the First Decision
Return for Revision	2024-12-20 12:36
Revised	2024-12-31 18:17
Second Decision	2025-02-07 06:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-17 06:30
Articles in Press	2025-02-17 06:30
Publication Fee Transferred	2025-01-07 13:58
Edit the Manuscript by Language Editor	2025-02-23 23:30
Typeset the Manuscript	2025-03-28 08:00

ISSN	1948-9358 (online)
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