Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	103590
Country	Canada

Category	Pediatrics
Manuscript Type	Case Control Study
Article Title	Prematurity is a risk factor of disorders of gut-brain interaction in adults: A case-control study
Manuscript Source	Invited Manuscript
All Author List	Olivier Courbette, Camille Girard-Bock, Anik Cloutier, Thuy Mai Luu, Anne Monique Nuyt and Christophe Faure
Funding Agency and Grant Number	Funding Agency Grant Number Sainte-Justine University Hospital Research Center excellence grant in 2020-2021
Corresponding Author	Olivier Courbette, MD, Department of Pediatric Gastroenterology, Sainte-Justine University Hospital Center, 3175 Chemin de la Côte Ste Catherine, Montreal H3T1C5, Quebec, Canada. olivier.courbette@gmail.com
Key Words	Constipation; Disorders of gut-brain interaction; Life stress; Pain; Prematurity; Preterm birth
Core Tip	In this study, using the Rome IV questionnaire, we assessed the prevalence of different disorders of gut-brain interaction (DGBI) in two populations: (1) Full-term; and (2) Preterm adults. Subsequently, we compared the results between these two populations and analyzed the risk factors for DGBI in the population of adults born prematurely using regression analysis. The group of adults born prematurely has a higher frequency of functional bowel problems. Functional constipation and functional gastroduodenal problems are substantially more common in prematurely born women than in controls. Ultimately, we confirm that extreme prematurity is a risk factor for developing a DGBI.
Citation	Courbette O, Girard-Bock C, Cloutier A, Luu TM, Nuyt AM, Faure C. Prematurity is a risk factor of disorders of gut-brain interaction in adults: A case-control study. World J Clin Pediatr 2025; In press

Received	2024-11-25 07:39
Peer-Review Started	2024-11-25 07:40
To Make the First Decision
Return for Revision	2025-03-11 02:27
Revised	2025-03-22 16:02
Second Decision	2025-04-15 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-15 10:14
Articles in Press	2025-04-15 10:14
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ISSN	2219-2808 (online)
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