| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Exosomal biomarkers: A novel frontier in the diagnosis of gastrointestinal cancers
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yuan Zhang, Ning-Ning Yue, Li-Yu Chen, Cheng-Mei Tian, Jun Yao, Li-Sheng Wang, Yu-Jie Liang, Dao-Ru Wei, Hua-Lin Ma and De-Feng Li |
| Funding Agency and Grant Number |
|
| Corresponding Author |
De-Feng Li, Associate Chief Physician, MD, PhD, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), No. 1017 Dongmen North Road, Luohu District, Shenzhen 518000, Guangdong Province, China. li.defeng@szhospital.com |
| Key Words |
Exosomes; Exosomal cargo; Liquid biopsy; Biomarkers; Gastrointestinal malignancies; Gastrointestinal tumor diagnosis |
| Core Tip |
In this comprehensive review, we explore the innovative potential of exosomal biomarkers in the diagnosis of gastrointestinal (GI) cancers. Liquid biopsy, a non-invasive diagnostic approach, has revolutionized early detection of GI cancers by leveraging the presence of exosomes in body fluids. These exosomes, rich in tumor-derived proteins, lipids, microRNAs, and RNAs, serve as reflective indicators of tumorigenesis and progression. Our analysis underscores the diagnostic, prognostic, and predictive value of exosomes, while also highlighting the clinical evidence supporting their application. We critically discuss the challenges in utilizing exosomes as biomarkers and their implications for early diagnosis, molecular analysis in GI cancers. |
| Citation |
<p>Zhang Y, Yue NN, Chen LY, Tian CM, Yao J, Wang LS, Liang YJ, Wei DR, Ma HL, Li DF. Exosomal biomarkers: A novel frontier in the diagnosis of gastrointestinal cancers. <i>World J Gastrointest Oncol</i> 2025; 17(4): 103591</p> |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
