Publication Name	World Journal of Diabetes
Manuscript ID	103616
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Pig bile powder maintains blood glucose homeostasis by promoting glucagon-like peptide-1 secretion via inhibiting farnesoid X receptor
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Min Sun, Jun-Liang Kuang, Hui-Heng Zhang, Xi-Xi Xia, Jie-Yi Wang, Dan Zheng, Ke-Jun Zhou, Ya-Jun Tang, Ai-Hua Zhao, Wei Jia, Guo-Xiang Xie and Xiao-Jiao Zheng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82122012 National Natural Science Foundation of China No. 82270917 National Natural Science Foundation of China No. 82170833 National Natural Science Foundation of China No. 82170601 Shanghai Sixth People’s Hospital Project No. ynjq202401 Shanghai Sixth People’s Hospital Project No. ynms202117 Shanghai Research Center for Endocrine and Metabolic Diseases No. 2022ZZ01002
Corresponding Author	Xiao-Jiao Zheng, Center for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, China. joyzheng99@sjtu.edu.cn
Key Words	Pig bile powder; Type 2 diabetes mellitus; Glucagon-like peptide 1; Farnesoid X receptor; Traditional Chinese medicine
Core Tip	Traditional Chinese medicine has several substances that regulate blood glucose in the treatment of type 2 diabetes mellitus. One of these substances is pig bile powder (BP). However, its mechanism of action remains unclear. This study demonstrated that BP treatment improved glucose tolerance and insulin sensitivity in a diabetic mouse model. Bile acids in the BP act as farnesoid X receptor antagonists and enhance glucagon-like peptide-1 production. Glucagon-like peptide-1 is a key hormone for glucose regulation. Our findings furthered the understanding of the therapeutic potential of BP for type 2 diabetes mellitus treatment.
Citation	Sun YM, Kuang JL, Zhang HH, Xia XX, Wang JY, Zheng D, Zhou KJ, Tang YJ, Zhao AH, Jia W, Xie GX, Zheng XJ. Pig bile powder maintains blood glucose homeostasis by promoting glucagon-like peptide-1 secretion via inhibiting farnesoid X receptor. World J Diabetes 2025; In press

Received	2024-12-16 07:23
Peer-Review Started	2024-12-17 00:55
To Make the First Decision
Return for Revision	2025-02-28 06:20
Revised	2025-03-13 06:42
Second Decision	2025-04-18 10:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-25 08:34
Articles in Press	2025-04-25 08:34
Publication Fee Transferred	2025-03-18 01:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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