Publication Name	World Journal of Transplantation
Manuscript ID	103656
Country	United Kingdom

Category	Transplantation
Manuscript Type	Retrospective Cohort Study
Article Title	Incidence, risk factors and survival outcomes of post-transplant tertiary hyperparathyroidism in kidney recipients
Manuscript Source	Unsolicited Manuscript
All Author List	Shmuel Hanson, Jorge Menendez Lorenzo, Chukwuma Austin Chukwu, Anirudh Rao, Rachel Middleton and Philip A Kalra
Funding Agency and Grant Number
Corresponding Author	Chukwuma Austin Chukwu, PhD, Department of Nephrology, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon Street, Liverpool L7 8YE, Mersey Side, United Kingdom. chukwuma.chukwu@rlbuht.nhs.uk
Key Words	Post-transplant tertiary hyperparathyroidism; Kidney transplantation; Parathyroid hormone; Parathyroidectomy; Calcimimetics; Graft survival; Risk factors; Mineral bone disorder; Fibroblast growth factor 23; Treatment outcomes
Core Tip	This study explores post-transplant tertiary hyperparathyroidism (PT-tHPT) in kidney transplant recipients, identifying elevated pre-transplant calcium and parathyroid hormone levels, prolonged dialysis duration, and acute rejection as key risk factors. PT-tHPT significantly increases the risks of graft loss and patient mortality. However, survival outcomes were comparable across treatment strategies: (1) Conservative management; (2) Calcimimetics; and (3) Parathyroidectomy. These findings highlight the need for optimized pre-transplant care and vigilant post-transplant monitoring to reduce PT-tHPT-related complications. Further research is essential to determine the most effective treatment strategy to improve outcomes and minimize morbidity and mortality associated with PT-tHPT.
Citation	Hanson S, Menendez Lorenzo J, Chukwu CA, Rao A, Middleton R, Kalra PA. Incidence, risk factors and survival outcomes of post-transplant tertiary hyperparathyroidism in kidney recipients. World J Transplant 2025; In press

Received	2024-11-29 08:13
Peer-Review Started	2024-11-29 08:14
To Make the First Decision
Return for Revision	2025-03-19 06:53
Revised	2025-07-06 22:03
Second Decision	2025-10-10 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-11 04:11
Articles in Press	2025-10-11 04:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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