Publication Name	World Journal of Critical Care Medicine
Manuscript ID	103708
Country	Greece

Category	Critical Care Medicine
Manuscript Type	Retrospective Cohort Study
Article Title	Length of stay, duration of mechanical ventilation, mortality, and acute kidney injury in acute respiratory failure requiring endotracheal intubation
Manuscript Source	Invited Manuscript
All Author List	Panagiotis Papamichalis, Katerina G Oikonomou, Maria Xanthoudaki, Sophia K Papathanasiou, Antonios Papadogoulas, Apostolia Lemonia Skoura, Asimina Valsamaki, Dimitrios Plageras, Michail Papamichalis, Periklis Katsiafylloudis, Evangelia Papapostolou, Konstantinos Mantzarlis, Athanasios Koukoulis, Gkreta Mavrommati, Panagiotis Giannakos and Achilleas Chovas
Funding Agency and Grant Number
Corresponding Author	Panagiotis Papamichalis, MD, PhD, Intensive Care Unit, General Hospital of Larissa, 1 Tsakalof, Larissa 41221, Thessaly, Greece. ppapamih@med.uth.gr
Key Words	Acute kidney injury; Peak airway pressure; Length of stay; Mortality; Acute respiratory failure; Arterial blood gases; COVID-19; Respiratory rate
Core Tip	Identifying prognostic factors in patients with acute respiratory failure requiring invasive mechanical/positive pressure ventilation remains a challenge to date. In the present study, the relationships of the epidemiological, respiratory, and arterial blood gas parameters to the four outcome measures of mortality, development of acute kidney injury, length of stay, and the duration of mechanical ventilation were evaluated. It was revealed that epidemiological factors such as the coronavirus disease 2019 presence and the respiratory parameters peak airway pressure and respiratory rate (RR) affected all the studied outcome measures. The possibility of improving outcomes by reducing the peak airway pressure and the RR and the observed association between RR and acute kidney injury needs further evaluation in future studies.
Citation	Papamichalis P, Oikonomou KG, Xanthoudaki M, Papathanasiou SK, Papadogoulas A, Skoura AL, Valsamaki A, Plageras D, Papamichalis M, Katsiafylloudis P, Papapostolou E, Mantzarlis K, Koukoulis A, Mavrommati G, Giannakos P, Chovas A. Length of stay, duration of mechanical ventilation, mortality, and acute kidney injury in acute respiratory failure requiring endotracheal intubation. World J Crit Care Med 2025; In press

Received	2024-11-29 07:16
Peer-Review Started	2024-12-02 02:05
To Make the First Decision
Return for Revision	2025-04-15 02:33
Revised	2025-04-28 17:36
Second Decision	2025-07-07 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-07 09:53
Articles in Press	2025-07-07 09:53
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ISSN	2220-3141(online)
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