Publication Name	World Journal of Stem Cells
Manuscript ID	103775
Country	India

Category	Cell & Tissue Engineering
Manuscript Type	Review
Article Title	Challenges in the clinical translation of stromal vascular fraction therapy in regenerative medicine
Manuscript Source	Invited Manuscript
All Author List	Naveen Jeyaraman, Sandeep Shrivastava, Ravi Velamoor Rangarajan, Arulkumar Nallakumarasamy, Swaminathan Ramasubramanian, Avinash Gandi Devadas, Secunda Rupert and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Stromal vascular fraction; Regenerative medicine; Cell therapy; Clinical translation; Adipose-derived stem cells
Core Tip	Stromal vascular fraction (SVF) therapy, derived from adipose tissue and containing a mix of cells, shows promise in treating conditions like osteoarthritis and chronic wounds. However, challenges such as biological variability, unclear mechanisms, regulatory issues, and scalability hinder clinical translation. Addressing these requires technological advancements, regulatory flexibility, and interdisciplinary collaboration. Innovations like automated isolation, advanced biomaterials, and CRISPR-based editing could enhance reliability. A structured roadmap, including preclinical research and large-scale trials, is essential for advancing SVF therapies. Future efforts should focus on standardizing protocols and generating real-world evidence to maximize SVF’s potential in regenerative medicine.
Citation	Jeyaraman N, Shrivastava S, Rangarajan RV, Nallakumarasamy A, Ramasubramanian S, Devadas AG, Rupert S, Jeyaraman M. Challenges in the clinical translation of stromal vascular fraction therapy in regenerative medicine. World J Stem Cells 2025; In press

Received	2024-12-03 15:31
Peer-Review Started	2024-12-06 00:16
To Make the First Decision
Return for Revision	2025-02-14 08:37
Revised	2025-03-13 08:47
Second Decision	2025-04-22 01:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-07 01:45
Articles in Press	2025-05-07 01:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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