Publication Name	World Journal of Critical Care Medicine
Manuscript ID	103782
Country	Türkiye

Category	Surgery
Manuscript Type	Clinical Trials Study
Article Title	Efficacy and safety of exosomes from Wharton’s Jelly-derived mesenchymal stem cells in traumatic brain injury
Manuscript Source	Invited Manuscript
All Author List	Serdar Kabatas, Erdinç Civelek, Eyüp Can Savrunlu, Necati Kaplan, Tunç Akkoc, Nurten Küçükçakır, Mehmet Bozkurt and Erdal Karaöz
Funding Agency and Grant Number
Corresponding Author	Serdar Kabatas, Department of Neurosurgery, University of Health Sciences Turkey, Gaziosmanpaşa Training and Research Hospital, Karayolları Mahallesi, Osmanbey Caddesi 616. Sokak No. 10, Gaziosmanpaşa, Istanbul 34255, Türkiye. kabatasserdar@hotmail.com
Key Words	Exosome therapy; Mesenchymal stem cells; Neuroprotection; Traumatic brain injury; Neuroregeneration
Core Tip	Mesenchymal stem cell-derived exosomes (MSCdE) therapy shows promise for traumatic brain injury (TBI) patients, with significant improvements in motor and cognitive function reflected in functional independence measure scores. The treatment was well tolerated, with mild, temporary side effects such as subfebrile fever and pain, and no serious adverse events reported. Enhanced Karnofsky Performance Scale scores suggest improved quality of life and functional status, supporting its potential for long-term recovery. While spasticity improvement was observed, it was not statistically significant, possibly due to mild baseline spasticity. These findings support MSCdE therapy as a potential treatment for TBI, warranting further validation through larger randomized controlled trials.
Citation	Kabatas S, Civelek E, Savrunlu EC, Kaplan N, Akkoc T, Küçükçakır N, Bozkurt M, Karaöz E. Efficacy and safety of exosomes from Wharton’s Jelly-derived mesenchymal stem cells in traumatic brain injury. World J Crit Care Med 2025; In press

Received	2024-12-04 08:52
Peer-Review Started	2024-12-05 05:56
To Make the First Decision
Return for Revision	2025-02-25 08:05
Revised	2025-04-01 01:59
Second Decision	2025-06-06 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-07 02:06
Articles in Press	2025-06-07 02:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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