Publication Name	World Journal of Gastroenterology
Manuscript ID	103848
Country	China

Category	Neurosciences
Manuscript Type	Basic Study
Article Title	Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model
Manuscript Source	Unsolicited Manuscript
All Author List	Bing Wang, Jia-Yi Ge, Jia-Ni Wu, Jia-Huan Xu, Xiao-Hua Cao, Na Chang, Xiang Zhou, Peng-Bo Jing, Xing-Jun Liu and Yong Wu
Funding Agency and Grant Number
Corresponding Author	Yong Wu, Chief Physician, MD, Department of Anesthesiology, The First People’s Hospital of Lianyungang, No. 6 Zhenhua East Street, Lianyungang 222000, Jiangsu Province, China. 18961325621@163.com
Key Words	Chronic pancreatitis; Abdominal pain; Endothelin; Endothelin A receptor; Calcitonin gene-related peptide; Macrophage infiltration; Microglia activation
Core Tip	Currently the mechanism underlying abdominal pain associated with chronic pancreatitis (CP) is not well understood. Utilizing dibutyltin dichloride-induced CP mouse model, it was found that the nociceptor-expressing endothelin A receptor (ETAR) is essential for the development of mechanical hypersensitivity following dibutyltin dichloride treatment. ETAR may contribute to this through regulating calcitonin gene-related peptide expression and activating immune cells. Therefore, targeting ETAR-dependent endothelin signaling in nociceptive sensory neurons may be a potential therapeutic approach for treating CP patients.
Citation	Wang B, Ge JY, Wu JN, Xu JH, Cao XH, Chang N, Zhou X, Jing PB, Liu XJ, Wu Y. Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model. World J Gastroenterol 2025; In press

Received	2024-12-04 03:52
Peer-Review Started	2024-12-04 03:52
To Make the First Decision
Return for Revision	2025-03-19 23:20
Revised	2025-03-30 13:52
Second Decision	2025-05-30 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-30 05:29
Articles in Press	2025-05-30 05:29
Publication Fee Transferred	2025-04-03 11:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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