Publication Name	World Journal of Experimental Medicine
Manuscript ID	103948
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	PI3K/AKT/GSK3β regulatory axis in bone mesenchymal stem cells initiates diabetic myocardial infarction via miR-142-3p
Manuscript Source	Unsolicited Manuscript
All Author List	Ning Gao, Peng-Fei Wu, Ming-Wen Wu, Yu-Meng Li, Xu Liang, Fei-Fei Wang, Xue-Jing Li, Qing-Qing Shen, Tian-Peng Zheng, Xiao-Ling Liu, Yi Sun and Liu-Xue Yang
Funding Agency and Grant Number	Funding Agency Grant Number Health Commission Project Z2014334 Natural Science Foundation of Guangxi Province, China 2020GXNSFAA238036
Corresponding Author	Yi Sun, Department of Toxicology, Guilin Medical University, No. 1, Zhiyuan Road, Lingui District, Guilin City, Guangxi Zhuang Autonomous Region, Guilin 541004, Guangxi Zhuang Autonomous Region, China. sunyide163@163.com
Key Words	Bones mesenchymal stem cells; Myocardial infarction in diabetes; MiR-142-3p; Liraglutide; Ferroptosis
Core Tip	This study demonstrated that using bones mesenchymal stem cells (BMCs) as an intervention can simultaneously reduce blood sugar levels and promote hypoxic myocardial recovery. However, when miR-142-3p expression in BMCs was low, there was a reduced therapeutic efficacy of BMCs and activation of PI3K/AKT/GSK-3β. The regulatory axis regulates changes in the protein expression levels of the ferroptosis-related genes GPX4/CHCHD6. These findings suggest that miR-142-3p via the PI3K/AKT/GSK-3β regulation axis that jointly inhibits ferroptosis, may be one of the therapeutic mechanisms of BMCs in diabetic myocardial infarction.
Citation	Gao N, Wu PF, WU MW, Li YM, Liang X, Wang FF, Li XJ, Shen QQ, Zheng TP, Liu XL, Sun Y, Yang LX. PI3K/AKT/GSK3β regulatory axis in bone mesenchymal stem cells initiates diabetic myocardial infarction via miR-142-3p. World J Exp Med 2025; In press

Received	2024-12-06 08:13
Peer-Review Started	2024-12-09 07:11
To Make the First Decision
Return for Revision	2025-02-28 06:53
Revised	2025-03-12 12:43
Second Decision	2025-04-27 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-27 08:06
Articles in Press	2025-04-27 08:06
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ISSN	2220-315x (online)
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