Publication Name	World Journal of Hepatology
Manuscript ID	104073
Country	China

Category	Rheumatology
Manuscript Type	Basic Study
Article Title	Effect of rapamycin nanoparticles in an animal model of primary biliary cholangitis
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Shu Yang, Xian-Rui Li, Zhi-Min Wang, Lin Zheng, Jin-Long Li, Xiao-Lin Cui, Yan-Biao Song, Jun-Ji Ma, Hui-Fang Guo, Li-Xia Gao and Xiao-Hui Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Cultivation Project of Hebei Natural Science Foundation-Precision Medicine Joint Fund No. H2021206239
Corresponding Author	Li-Xia Gao, Chief Physician, MD, PhD, Professor, Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. 27100287@hebmu.edu.cn
Key Words	Primary biliary cholangitis; Rapamycin; Nanoparticles; Mouse model; Anti-mitochondrial antibodies; Cytokine
Core Tip	Primary biliary cholangitis (PBC) is a chronic autoimmune-mediated cholestatic liver disease, which can gradually progress to liver fibrosis, cirrhosis. The global incidence of PBC has been increasing year by year in recent decades. But there are few effective drugs, the effect of nanoparticles encapsulating rapamycin on the treatment of PBC using an animal model is examined in this paper, targeting at new approaches for the treatment of PBC.
Citation	Yang YS, Li XR, Wang ZM, Zheng L, Li JL, Cui XL, Song YB, Ma JJ, Guo HF, Gao LX, Zhou XH. Effect of rapamycin nanoparticles in an animal model of primary biliary cholangitis. World J Hepatol 2025; In press

Received	2024-12-16 03:43
Peer-Review Started	2024-12-16 03:43
To Make the First Decision
Return for Revision	2025-02-10 06:09
Revised	2025-02-24 14:42
Second Decision	2025-05-21 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-21 12:34
Articles in Press	2025-05-21 12:34
Publication Fee Transferred	2025-03-05 15:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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