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Publication Name World Journal of Gastroenterology
Manuscript ID 104117
Country China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease
Manuscript Source Unsolicited Manuscript
All Author List Feng Zhu, Bing-Ru Lin, Shi-Hua Lin, Chao-Hui Yu and Yun-Mei Yang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China No. 820300089
Corresponding Author Chao-Hui Yu, Chief Physician, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zyyyych@zju.edu.cn
Key Words Aging; Metabolic dysfunction-associated steatotic liver disease; Vitamin D receptor; Steatosis; Hepatocytes
Core Tip We showed that aging exacerbated the pathogenesis of metabolic dysfunction-associated steatotic liver disease. Hepatic-specific knockdown of vitamin D receptor alleviated the progression of aging-related metabolic dysfunction-associated steatotic liver disease. Vitamin D receptor is a crucial factor implicated in steatosis.
Citation <p>Zhu F, Lin BR, Lin SH, Yu CH, Yang YM. Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease. <i>World J Gastroenterol</i> 2025; 31(14): 104117</p>
Received
2024-12-11 08:54
Peer-Review Started
2024-12-11 08:54
To Make the First Decision
Return for Revision
2025-02-08 23:20
Revised
2025-02-21 09:20
Second Decision
2025-03-20 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-03-21 06:41
Articles in Press
2025-03-21 06:41
Publication Fee Transferred
2025-02-24 08:18
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-04-07 03:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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