Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	104234
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Intravenous proton pump inhibitors vs oral potassium competitive acid blockers before endoscopic treatment of bleeding peptic ulcers
Manuscript Source	Unsolicited Manuscript
All Author List	Na Rae Lim and Woo Chul Chung
Funding Agency and Grant Number
Corresponding Author	Woo Chul Chung, MD, PhD, Professor, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University, Jungbu-daero 93, Seoul 16247, South Korea. jwchulkr@catholic.ac.kr
Key Words	Peptic ulcer; Bleeding; Proton pump inhibitor; Potassium competitive acid blocker; Ulcer bleeding
Core Tip	This study compared the effectiveness of intravenous proton pump inhibitors (PPIs) and oral potassium competitive acid blockers (PCABs) in managing non-variceal upper gastrointestinal bleeding prior to emergency endoscopy. PPI injection and PCAB administration groups showed no significant differences in bleeding severity. However, the PCAB group demonstrated significantly fewer ulcer lesions with recent bleeding stigmata and required fewer therapeutic endoscopic interventions. Additionally, re-bleeding events were more frequent in the PPI group. These findings suggest that pre-endoscopic administration of PCABs may be more effective than PPIs and could potentially reduce mortality associated with ulcer bleeding.
Citation	<p>Lim NR, Chung WC. Intravenous proton pump inhibitors vs oral potassium competitive acid blockers before endoscopic treatment of bleeding peptic ulcers. <i>World J Gastrointest Endosc</i> 2025; 17(6): 104234</p>

Received	2024-12-16 08:18
Peer-Review Started	2024-12-16 08:19
To Make the First Decision
Return for Revision	2025-03-01 06:33
Revised	2025-03-29 05:00
Second Decision	2025-05-13 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-13 08:54
Articles in Press	2025-05-13 08:54
Publication Fee Transferred	2025-04-03 02:32
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-04 01:41

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com