Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	104689
Country	Russia

Category	Pediatrics
Manuscript Type	Retrospective Cohort Study
Article Title	Analysis of fatal outcomes of patients with mucopolysaccharidosis type II according to the Russian mucopolysaccharidosis registry
Manuscript Source	Invited Manuscript
All Author List	Natalia Buchinskaya, Anastasia Vechkasova, Nato Vashakmadze, Leyla Namazova-Baranova, Dmitry Ivanov, Ekaterina Zakharova, Sergei Kutsev and Mikhail Kostik
Funding Agency and Grant Number
Corresponding Author	Mikhail Kostik, MD, PhD, Professor, Hospital Pediatry, Saint-Petersburg State Pediatric Medical University, Lytovskaya 2, Saint-Petersburg 194100, Sankt-Peterburg, Russia. kost-mikhail@yandex.ru
Key Words	Mucopolysaccharidosis type II; IDS gene; Genotype-phenotype; Long-term outcomes; Russian Federation
Core Tip	Mucopolysaccharidosis type II is a rare lysosomal storage disease characterized by the progression of multiorgan dysfunction and increased mortality rates. The assessment of the death outcomes might improve the survival of these patients. High birth weight, delayed diagnosis, delayed enzyme replacement treatment, any signs of central nervous system involvement, and progressive impossibility of independent walking were the main predictors of the fatal outcome.
Citation	Buchinskaya N, Vechkasova A, Vashakmadze N, Namazova-Baranova L, Ivanov D, Zakharova E, Kutsev S, Kostik M. Analysis of fatal outcomes of patients with mucopolysaccharidosis type II according to the Russian mucopolysaccharidosis registry. World J Clin Pediatr 2025; In press

Received	2024-12-31 04:13
Peer-Review Started	2024-12-31 04:13
To Make the First Decision
Return for Revision	2025-03-19 02:54
Revised	2025-04-01 16:31
Second Decision	2025-04-09 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-09 07:59
Articles in Press	2025-04-09 07:59
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Typeset the Manuscript

ISSN	2219-2808 (online)
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