Publication Name	World Journal of Gastroenterology
Manuscript ID	104794
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research
Manuscript Source	Invited Manuscript
All Author List	Cheng-Fei Zhao, Xiao-Ling Liu, Ning-Bi Wu and Zhi-Feng Xu
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Fujian Province No. 2023J01160 Scientific Research Project of Putian University No. 2022059 Special Project for Outstanding Young Talents of Putian University No. 2024072
Corresponding Author	Zhi-Feng Xu, Chief Physician, Department of Cardiothoracic Surgery, Affiliated Hospital of Putian University, No. 999 Dongzhen Road, Licheng District, Putian 351100, Fujian Province, China. zhifengxu1972@163.com
Key Words	Advanced gastric cancer; Triglyceride-glucose index; Prognostic indicator; Immunotherapy; Insulin resistance
Core Tip	Gastric cancer (GC) is one of the most prevalent and deadly cancers worldwide, with advanced stages associated with poor survival outcomes. The triglyceride-glucose (TyG) index is a comprehensive statistical measure that incorporates fasting triglyceride and fasting glucose levels. Yao et al reported the effect of the TyG index on the prognosis of advanced GC patients undergoing combination therapy with sintilimab (a programmed cell death protein 1 inhibitor) and chemotherapy. This editorial critically analyzes the study’s clinical significance, its potential for enhancing personalized treatment strategies, and the innovative future research directions that could solidify the role of the TyG index in clinical oncology.
Citation	<p>Zhao CF, Liu XL, Wu NB, Xu ZF. Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research. <i>World J Gastroenterol</i> 2025; 31(17): 104794</p>

Received	2025-01-02 08:58
Peer-Review Started	2025-01-02 08:58
To Make the First Decision
Return for Revision	2025-02-13 22:45
Revised	2025-03-29 06:55
Second Decision	2025-04-18 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-18 05:45
Articles in Press	2025-04-18 05:45
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-04-20 14:41
Typeset the Manuscript	2025-04-23 08:02

ISSN	1007-9327 (print) and 2219-2840 (online)
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