Publication Name	World Journal of Orthopedics
Manuscript ID	104853
Country	China

Category	Orthopedics
Manuscript Type	Review
Article Title	Deciphering the etiology of congenital scoliosis: A genetic and epigenetic perspective
Manuscript Source	Unsolicited Manuscript
All Author List	Rui Zhao, Ji-Rong Zhao, Xu Xue and Dong Ma
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82460940 Major Project of Gansu Province Joint Fund 23JRRA1519 Key Science and Technology Project of Gansu Province 21ZD4FA009 Natural Science Foundation of Gansu Province 24JRRA1040 Gansu Province Famous Traditional Chinese Medicine Inheritance Studio Project
Corresponding Author	Ji-Rong Zhao, Chief Physician, Professor, Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, No. 35 Dingxi East Road, Chengguan District, Lanzhou 730000, Gansu Province, China. zhaojirong0709@163.com
Key Words	Congenital scoliosis; Genetics; Epigenetics; Genetic variants; Susceptibility factors
Core Tip	Congenital scoliosis (CS) is a common spinal deformity with complex and not fully understood causes. This review highlights recent advancements in genetic and epigenetic research, focusing on the identification of genetic variants, susceptibility factors, and their regulatory mechanisms. By examining genetic markers, chromosomal abnormalities, and epigenetic modifications, we explore how genetic predisposition interacts with environmental influences in the pathogenesis of CS. This integrated analysis aims to enhance understanding of CS etiology, guiding future clinical interventions and the development of personalized therapeutic approaches.
Citation	Zhao R, Zhao JR, Xue X, Ma D. Deciphering the etiology of congenital scoliosis: A genetic and epigenetic perspective. World J Orthop 2025; In press

Received	2025-01-06 03:55
Peer-Review Started	2025-01-06 03:55
To Make the First Decision
Return for Revision	2025-02-11 09:08
Revised	2025-02-24 13:02
Second Decision	2025-05-21 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-21 13:20
Articles in Press	2025-05-21 13:20
Publication Fee Transferred	2025-03-15 11:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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