Publication Name	World Journal of Gastroenterology
Manuscript ID	104901
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Conversion treatment for advanced intrahepatic cholangiocarcinoma: Opportunities and challenges
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Jie Liu, Mi Zhou, Tong Yuan, Zhi-Yong Huang and Zun-Yi Zhang
Funding Agency and Grant Number
Corresponding Author	Zun-Yi Zhang, Associate Professor, MD, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. zunyizhangtjmu@163.com
Key Words	Locoregional therapies; Immunotherapy; Chemotherapy; Combination therapy; Downstaging; Conversion treatment; Intrahepatic cholangiocarcinoma
Core Tip	The conversion treatment for unresectable intrahepatic cholangiocarcinoma (ICC) can reduce tumor burden and enhance the likelihood of surgical resection. Chemotherapy is still the base treatment for advanced ICC. However, locoregional therapies and systemic therapies are promising treatment strategies for advanced ICC, aiming to enhance tumor response and improve patient outcomes. Achieving an adequate future liver remnant is crucial to prevent posthepatectomy liver failure; techniques are being investigated to enhance future liver remnant and improve outcomes in patients with advanced ICC.
Citation	<p>Liu JJ, Zhou M, Yuan T, Huang ZY, Zhang ZY. Conversion treatment for advanced intrahepatic cholangiocarcinoma: Opportunities and challenges. <i>World J Gastroenterol</i> 2025; 31(15): 104901</p>

Received	2025-01-05 15:02
Peer-Review Started	2025-01-05 15:02
To Make the First Decision
Return for Revision	2025-02-13 22:16
Revised	2025-02-22 08:06
Second Decision	2025-03-26 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-26 05:48
Articles in Press	2025-03-26 05:48
Publication Fee Transferred	2025-02-26 02:31
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-14 03:20

ISSN	1007-9327 (print) and 2219-2840 (online)
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