Publication Name	World Journal of Diabetes
Manuscript ID	104973
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Ras homolog enriched in brain 1 regulates β cell mass and β cell function via mTORC1/AMPK/Notch1 pathways
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Yang, Wan-Juan Song and Jing-Jing zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82430029 National Natural Science Foundation of China 82330025 National Natural Science Foundation of China 82370807 National Natural Science Foundation of China 82070807 Leading Talents Program of Hunan Province 2022RC3078 Natural Science Foundation of Hunan Province, China 2021JJ30976
Corresponding Author	Jing-Jing zhang, MD, PhD, National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Renmin middle road, Changsha 410011, Hunan Province, China. doctorzhangjj@csu.edu.cn
Key Words	Rheb1; β cells; Diabetes; mTOR; AMP-activated protein kinase; Hepatocyte nuclear factor4-alpha
Core Tip	Mechanisms underlying β cell dysfunction in diabetes remains unclear, our study explores the role of Ras homolog enriched in brain 1 (Rheb1) in regulating β-cell function and proliferation. The researchers found that Rheb1 is more highly expressed in islets from younger individuals (under 18) compared to adults. Rheb1 promotes β-cell proliferation through both the mTORC1 and AMP-activated protein kinase pathways, rather than relying solely on mTORC1. Moreover, Rheb1 also upregulated key transcription factor HNF4α in β cells. These findings suggest that Rheb1 plays a vital role in β-cell growth and function, making it a promising target for diabetes therapy.
Citation	<p>Yang Y, Song WJ, zhang JJ. Ras homolog enriched in brain 1 regulates β cell mass and β cell function via mTORC1/AMPK/Notch1 pathways. <i>World J Diabetes</i> 2025; 16(6): 104973</p>

Received	2025-01-10 10:29
Peer-Review Started	2025-01-13 00:57
To Make the First Decision
Return for Revision	2025-02-11 07:41
Revised	2025-02-19 11:56
Second Decision	2025-03-17 07:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-03 07:25
Articles in Press	2025-04-03 07:25
Publication Fee Transferred	2025-02-26 05:20
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-27 02:50

ISSN	1948-9358 (online)
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