Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	105033
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Association between hereditary spherocytosis and gallstone disease: Pathophysiology, diagnosis, and management
Manuscript Source	Invited Manuscript
All Author List	Shan Cong, Yu-Ning Wang, Jun-Rong Wang and Rui-Heng Duan
Funding Agency and Grant Number
Corresponding Author	Jun-Rong Wang, Professor, Department of Gynaecology and Obstetrics, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun 130022, Jilin Province, China. junrongwang_2019@yeah.net
Key Words	Hereditary spherocytosis; Gallstone disease; Hemolysis; Bilirubin metabolism; Multidisciplinary management
Core Tip	Hereditary spherocytosis (HS) predisposes patients to gallstone disease due to chronic hemolysis and elevated bilirubin levels. This review explores the pathophysiological mechanisms, clinical manifestations, and diagnostic strategies for hereditary spherocytosis-related gallstones. Key insights include the importance of ultrasonography and magnetic resonance cholangiopancreatography for early detection, tailored management strategies such as splenectomy and cholecystectomy, and emerging preventive approaches, including lifestyle modifications, pharmacological therapies, and novel treatments like nanoprodrugs and probiotics. Addressing research gaps in genetic predisposition, microbial influences, and biomarkers will further enhance prevention and treatment, particularly in pediatric populations, emphasizing a multidisciplinary approach for optimized outcomes.
Citation	Cong S, Wang YN, Wang JR, Duan RH. Association between hereditary spherocytosis and gallstone disease: Pathophysiology, diagnosis, and management. World J Gastrointest Surg 2025; In press

Received	2025-01-10 09:43
Peer-Review Started	2025-01-10 09:43
To Make the First Decision
Return for Revision	2025-03-18 06:01
Revised	2025-03-18 10:55
Second Decision	2025-05-21 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-21 06:30
Articles in Press	2025-05-21 06:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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