Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	105034
Country	China

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Resveratrol: A promising agent in targeting senescent cancer-associated fibroblasts to inhibit pancreatic cancer progression
Manuscript Source	Unsolicited Manuscript
All Author List	Hao Qin
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82304151
Corresponding Author	Hao Qin, PhD, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. haoqin@bjmu.edu.cn
Key Words	Pancreatic cancer; Cancer-associated fibroblasts; Resveratrol; Tumor microenvironment; Senescence-associated secretory phenotype
Core Tip	ancreatic cancer remains a challenging disease with limited treatment options, largely due to the tumor microenvironment (TME) and its cancer-associated fibroblasts (CAFs). Senescent CAFs, through their senescence-associated secretory phenotype (SASP), contribute to tumor progression. Recent studies have explored the potential of resveratrol, a natural polyphenolic compound, to target these senescent CAFs. Resveratrol reduces the number of senescent CAFs, downregulates SASP factors, and disrupts tumor-promoting interactions in the TME. These findings suggest that resveratrol could serve as an effective adjunctive therapy for pancreatic cancer by modulating the TME and inhibiting cancer cell proliferation and metastasis.
Citation	Qin H. Resveratrol: A promising agent in targeting senescent cancer-associated fibroblasts to inhibit pancreatic cancer progression. World J Gastrointest Oncol 2025; In press

Received	2025-01-10 09:29
Peer-Review Started	2025-01-10 09:29
To Make the First Decision
Return for Revision	2025-02-14 01:52
Revised	2025-02-19 03:03
Second Decision	2025-02-26 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-26 06:36
Articles in Press	2025-02-26 06:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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