Publication Name	World Journal of Diabetes
Manuscript ID	105156
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Meta-Analysis
Article Title	Abnormal peripheral cellular immune profiles in gestational diabetes mellitus: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Yang, Quan-Zhou Xiao, Jian Zhou and Ya-Qi Wang
Funding Agency and Grant Number
Corresponding Author	Ya-Qi Wang, National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. 238202062@csu.edu.cn
Key Words	Gestational diabetes mellitus; Peripheral immune cell; Immune dysregulation; Meta-analysis
Core Tip	Gestational diabetes mellitus (GDM) affects pregnancies globally, leading to serious complications for both mothers and their offspring. GDM is associated with immune dysregulation, including alterations in immune cell profiles. This study analyzed 19 studies and found increased CD4+ T cells and reduced Treg cells in GDM patients, indicating an abnormal immune response. Other immune cells, like CD3+ T cells and NK cells, showed no significant changes. The findings suggest that GDM may not only involve dysglycemia but also immune disorders, highlighting the potential for immune-targeted therapies in GDM management.
Citation	Yang Y, Xiao QZ, Zhou J, Wang YQ. Abnormal peripheral cellular immune profiles in gestational diabetes mellitus: A meta-analysis. World J Diabetes 2025; In press

Received	2025-01-15 11:08
Peer-Review Started	2025-01-17 01:11
To Make the First Decision
Return for Revision	2025-03-25 07:13
Revised	2025-04-24 08:48
Second Decision	2025-06-03 10:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-10 08:28
Articles in Press	2025-06-10 08:28
Publication Fee Transferred	2025-05-02 05:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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