Publication Name	World Journal of Diabetes
Manuscript ID	105219
Country	China

Category	Health Care Sciences & Services
Manuscript Type	Clinical Trials Study
Article Title	Efficacy of Xiaokeqing granules and lifestyle intervention in treating prediabetes mellitus considering metabolomic biomarkers: A randomised controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Dong Zhao, Meng-Zhu Guo, Yi Zhang, Shao-Hua Zhu, Ya-Ting Wang, Yan-Ping Zhang, Xin Liu, Si Cheng, Fei Wang, Qi Xu, Nuo-Bing Ruan and Zhao-Hui Fang
Funding Agency and Grant Number	Funding Agency Grant Number Open Bidding for Selecting the Best Candidates for Xin’an Medicine and the Modernization of Traditional Chinese Medicine of IHM No. 2023CXMMTCM024 Open Bidding for Selecting the Best Candidates for Xin’an Medicine and the Modernization of Traditional Chinese Medicine of IHM No. 2023CXMMTCM003 Anhui University Collaborative Innovation Project No. GXXT-2020-025 Scientific Research Project of Health and Wellness in Anhui Province No. AHWJ2023BAc10002 Anhui Province New Era Education Quality Project No. 2023 gjxslt014 Clinical and Translational Research Project of Anhui Province No. 202427b10020046
Corresponding Author	Zhao-Hui Fang, Department of Endocrinology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei 230031, Anhui Province, China. fangzhaohui1111@163.com
Key Words	Prediabetes mellitus; Xiaokeqing granules; Lifestyle; Two-hour postprandial glucose; Metabolomics; Tryptophan metabolism
Core Tip	In this study, Xiaokeqing granules constitute a new class-three traditional Chinese medicine. They can improve 2-hour postprandial glucose in participants with prediabetes mellitus with yin deficiency syndrome with excessive heat according to a preliminary investigation and an exploratory randomised controlled trial. Groenlandicine and kaempferol are the main Xiaokeqing granule constituents absorbed into the blood. N-Nervonoyl methionine and 5-hydroxy-L-tryptophan are potential biomarkers for the effectiveness of Xiaokeqing granules and lifestyle interventions.
Citation	Zhao JD, Guo MZ, Zhang Y, Zhu SH, Wang YT, Zhang YP, Liu X, Cheng S, Wang F, Xu Q, Ruan NB, Fang ZH. Efficacy of Xiaokeqing granules and lifestyle intervention in treating prediabetes mellitus considering metabolomic biomarkers: A randomised controlled trial. World J Diabetes 2025; In press

Received	2025-01-15 12:14
Peer-Review Started	2025-01-17 01:06
To Make the First Decision
Return for Revision	2025-03-21 06:51
Revised	2025-04-02 16:51
Second Decision	2025-05-23 00:45
Accepted by Journal Editor-in-Chief	2025-05-27 14:51
Accepted by Executive Editor-in-Chief	2025-05-28 06:46
Articles in Press	2025-05-28 06:46
Publication Fee Transferred	2025-04-03 14:29
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ISSN	1948-9358 (online)
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