Publication Name	World Journal of Psychiatry
Manuscript ID	105249
Country	China

Category	Psychiatry
Manuscript Type	Clinical Trials Study
Article Title	Efficacy of Pediococcus acidilactici CCFM6432 in alleviating anhedonia in major depressive disorder: A randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Du-Xing Li, Qi-Ming Hu, Chen-Chen Xu, Hong-Yu Yang, Ji-Kang Liu, Yi-Fan Sun, Gang Wang, Jun Wang and Zhen-He Zhou
Funding Agency and Grant Number	Funding Agency Grant Number the Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee BJ2023086 Wuxi Taihu Talent Project WXTTP 2021
Corresponding Author	Jun Wang, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, 156 Qianrong Road, Binhu District, Wuxi 214151, Jiangsu Province, China. woodfish2@126.com
Key Words	Anhedonia; Probiotics; Depression; Event-related potentials; Reward processing
Core Tip	Anhedonia, a core symptom of major depressive disorder (MDD), often exhibits poor responsiveness to conventional antidepressants, substantially impairing long-term prognosis. In our randomized controlled trial, adjunctive administration of Pediococcus acidilactici CCFM6432 alongside standard antidepressants demonstrated marked improvements in anhedonia, particularly anticipatory deficits, among MDD patients. Efficacy was quantified through the Temporal Experience of Pleasure Scale and task-specific electroencephalography biomarkers during the Guessing-Door Task, revealing enhanced reward anticipation neural signatures. These findings highlight CCFM6432's clinical potential in addressing anhedonia, with mechanistic implications for gut microbiota-brain axis modulation.
Citation	Li DX, Hu QM, Xu CC, Yang HY, Liu JK, Sun YF, Wang G, Wang J, Zhou ZH. Efficacy of Pediococcus acidilactici CCFM6432 in alleviating anhedonia in major depressive disorder: A randomized controlled trial. World J Psychiatry 2025; In press

Received	2025-01-16 03:00
Peer-Review Started	2025-01-16 03:01
To Make the First Decision
Return for Revision	2025-03-18 09:09
Revised	2025-03-28 09:12
Second Decision	2025-05-09 09:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-20 08:17
Articles in Press	2025-05-20 08:17
Publication Fee Transferred	2025-04-01 08:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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