Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	105264
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Nav1.6 drives colorectal cancer proliferation and invasion through MAPK signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Ming Zhao, Wan-Ying Hong, Jian-Guang Xu, Shui-Quan Lin, Ming-Sheng Liu, Li-Hui Wang, Xu-Li Jiang, Ming Sang and Yang-Bo Lv
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Project of Quzhou of China 2021Y011 Beijing Science and Technology Innovation Medical Development Foundation KC2021-JX-0186-81
Corresponding Author	Yang-Bo Lv, Department of Colorectal Surgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, No. 100 Minjiang Avenue, Quzhou 324002, Zhejiang Province, China. lyb20110115@163.com
Key Words	Nav1.6; Colorectal cancer; Weighted correlation network analysis; MAPK signaling; Cancer proliferation
Core Tip	Voltage-gated sodium channels are prominently expressed in various tumors and play a crucial role in tumor metastasis and invasion. Our research identified 575 differentially expressed genes related to Nav1.6 in colorectal cancer (CRC), particularly enriched in MAPK signaling pathways. Tissue microarray revealed heightened Nav1.6 levels in CRC tissues. The cytoplasmic expression of Nav1.6 increases with T staging. Knockdown of SCN8A in colon tumor cells significantly decreased cell proliferation and invasion, along with downregulation of key proteins in the RAF-MAPK pathway. These findings suggest that Nav1.6 enhances CRC cell proliferation and invasion through modulation of the MAPK signaling pathway.
Citation	Zhao LM, Hong WY, Xu JG, Lin SQ, Liu MS, Wang LH, Jiang XL, Sang M, Lv YB. Nav1.6 drives colorectal cancer proliferation and invasion through MAPK signaling pathway. World J Gastrointest Oncol 2025; In press

Received	2025-01-18 06:51
Peer-Review Started	2025-01-18 06:51
To Make the First Decision
Return for Revision	2025-02-26 07:42
Revised	2025-03-12 07:45
Second Decision	2025-04-21 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-21 08:36
Articles in Press	2025-04-21 08:36
Publication Fee Transferred	2025-03-13 05:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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