Publication Name	World Journal of Gastroenterology
Manuscript ID	105347
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Protein-losing enteropathy and multiple vasculature dysplasia in LZTR1-related Noonan syndrome: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Qiu-Ju Tian, Lu-Jia Zhang, Qun Zhang, Feng-Chao Liu, Man Xie, Jin-Zhen Cai and Wei Rao
Funding Agency and Grant Number	Funding Agency Grant Number Shandong Provincial Natural Science Fundation of China ZR2023QH015 Qingdao Municipal Natural Science Fundation of China 23-2-1-134-zyyd-jch
Corresponding Author	Wei Rao, MD, PhD, Professor, Division of Hepatology, Liver Disease Center, The Affiliated Hospital of Qingdao University, No. 59 Haier Road, Laoshan District, Qingdao 266100, Shandong Province, China. qdfy_raowei@qdu.edu.cn
Key Words	Noonan syndrome; Leucine zipper-like transcription regulator 1; Protein-losing enteropathy; Porto-sinusoidal vascular disease; Hypoproteinemia; Intestinal lymphangiectasia; Case report
Core Tip	Protein-losing enteropathy (PLE) is rarely reported with Noonan syndrome. This case reported a rare mutation in leucine zipper-like transcription regulator 1 related to Noonan syndrome, thoracic duct abnormalities, small intestinal lymphangiectasia, PLE in a juvenile female with multiple vasculature dysplasia and congenital deformity of the little finger, and the successful treatment of hypoalbuminemia by microsurgical relief of the thoracic duct outlet obstruction. As far as we know, this is the first case describing PLE associated with Noonan syndrome caused by a rare genetic mutation in leucine zipper-like transcription regulator 1 (c.850C>T:P.R284C) with newly reported manifestations. Additionally, this report provides new evidence about the management of Noonan syndrome.
Citation	<p>Tian QJ, Zhang LJ, Zhang Q, Liu FC, Xie M, Cai JZ, Rao W. Protein-losing enteropathy and multiple vasculature dysplasia in LZTR1-related Noonan syndrome: A case report and review of literature. <i>World J Gastroenterol</i> 2025; 31(17): 105347</p>

Received	2025-01-27 08:16
Peer-Review Started	2025-01-27 08:18
To Make the First Decision
Return for Revision	2025-03-18 21:07
Revised	2025-03-31 18:53
Second Decision	2025-04-21 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-21 05:23
Articles in Press	2025-04-21 05:23
Publication Fee Transferred	2025-04-01 12:29
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-23 08:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com