Publication Name	World Journal of Critical Care Medicine
Manuscript ID	105350
Country	United States

Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Methylene blue in the critical care setting
Manuscript Source	Invited Manuscript
All Author List	Praveen R Elmati, Teja Nagaradona, Vikas Raghove, Gowthami SK Jagirdhar and Salim Surani
Funding Agency and Grant Number
Corresponding Author	Salim Surani, MD, Professor, Department of Medicine and Pharmacology, Texas AM University, 40 Bizzell Street, College Station, TX 77843, United States. srsurani@hotmail.com
Key Words	Methylene blue; Critical care; Intensive care; Septic shock; Vasoplegic shock; Distributive shock
Core Tip	Methylene blue is a promising medication with various benefits due to its inhibition of guanylate cyclase, anti-inflammatory effects, and nitric oxide inhibition. It has been researched in septic shock, distributive shock in cardiac procedures, anaphylaxis, and organ transplant procedures. It is a safe medication based on literature with rare documented adverse events at lower doses. Its role as an adjunct to vasopressors needs to be further researched, including the definition of the dose, initiation time, and usage duration.
Citation	Elmati PR, Nagaradona T, Raghove V, Jagirdhar GSK, Surani S. Methylene blue in the critical care setting. World J Crit Care Med 2025; In press

Received	2025-01-20 10:44
Peer-Review Started	2025-01-20 10:45
To Make the First Decision
Return for Revision	2025-03-10 01:50
Revised	2025-03-21 23:46
Second Decision	2025-04-21 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-21 08:14
Articles in Press	2025-04-21 08:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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