Publication Name	World Journal of Critical Care Medicine
Manuscript ID	105428
Country	Pakistan

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Acute liver failure etiology, clinical manifestation and outcomes in adults: Experience of tertiary care hospital in Karachi
Manuscript Source	Invited Manuscript
All Author List	Nazish Butt, Sabir Ali, Hanisha Khemani and Khalid Mumtaz
Funding Agency and Grant Number
Corresponding Author	Nazish Butt, Associate Professor, Department of Gastroenterology, Jinnah Postgraduate Medical Centre, Rafiqui, Sarwar Shaheed Rd, Karachi Cantonment, Karachi 05444, Pakistan. drnazishbutt@gmail.com
Key Words	Acute liver failure; Hepatitis E virus; Hepatic encephalopathy; Jaundice; Mortality
Core Tip	This study investigates the etiological factors, clinical manifestations, and outcomes of acute liver failure in a tertiary care hospital in Pakistan. Hepatitis E virus was the predominant cause, particularly in pregnant women, with high associated mortality. Jaundice, hepatic encephalopathy, sepsis, and fatigue were significant predictors of poor prognosis. Limited liver transplant facilities contribute to increased mortality, highlighting the urgent need for early referral, risk factor management, and improved supportive care to enhance patient survival.
Citation	<p>Butt N, Ali S, Khemani H, Mumtaz K. Acute liver failure etiology, clinical manifestation and outcomes in adults: Experience of tertiary care hospital in Karachi. <i>World J Crit Care Med</i> 2025; 14(3): 105428</p>

Received	2025-01-22 08:51
Peer-Review Started	2025-01-22 08:51
To Make the First Decision
Return for Revision	2025-03-05 08:35
Revised	2025-03-15 14:26
Second Decision	2025-04-01 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-01 11:20
Articles in Press	2025-04-01 11:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-01 06:44

ISSN	2220-3141(online)
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