Publication Name	World Journal of Gastroenterology
Manuscript ID	105466
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Focal adhesion kinase: A promising regulator of colitis-associated healing
Manuscript Source	Invited Manuscript
All Author List	Kaitlyn Kaye Malek, Balawant Kumar, Rizwan Ahmad, Amar Singh and Marc D Basson
Funding Agency and Grant Number
Corresponding Author	Marc D Basson, College of Medicine, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, OH 44272, United States. mbasson@neomed.edu
Key Words	Focal adhesion kinase; Inflammatory bowel disease; Mucosal healing; Gut barrier integrity; Colitis pathophysiology
Core Tip	Focal adhesion kinase (FAK) plays a critical role in gastrointestinal mucosal healing via various key cellular processes. Small molecule FAK activators, such as ZINC40099027 or analogs, selectively enhance the activity of FAK to promote epithelial cell migration and wound closure. Therefore, ZINC40099027 and similar agents demonstrate promise in treating gastrointestinal mucosal injuries, such as ulcers or inflammatory bowel disease. Their two-fold approach in perpetuating repair mechanisms while minimizing oncogenic pathogenesis offers a therapeutic solution that is a safer, long-term treatment option for complex mucosal injuries.
Citation	Malek KK, Kumar B, Ahmad R, Singh A, Basson MD. Focal adhesion kinase: A promising regulator of colitis-associated healing. World J Gastroenterol 2025; In press

Received	2025-01-23 06:07
Peer-Review Started	2025-01-23 06:07
To Make the First Decision
Return for Revision	2025-04-09 06:39
Revised	2025-06-02 02:39
Second Decision	2025-08-14 03:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 05:55
Articles in Press	2025-08-15 05:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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