Publication Name	World Journal of Stem Cells
Manuscript ID	105491
Country	China

Category	Sport Sciences
Manuscript Type	Basic Study
Article Title	Fibro-adipogenic progenitors prevent skeletal muscle degeneration at acute phase upon tendon rupture in a murine tibialis anterior tenotomy model
Manuscript Source	Unsolicited Manuscript
All Author List	Zhe-Ci Ding, Juan-Juan He, Lu-Ze Shi, Jin Qian, Shu-Hao Mei, Xia Kang and Ji-Wu Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82172509
Corresponding Author	Ji-Wu Chen, Chief Physician, MD, PhD, Professor, Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, No. 85 Wujin Road, Shanghai 200080, China. jeevechen@gmail.com
Key Words	Fibro-adipogenic progenitors; Skeletal muscle degeneration; Tibialis anterior tenotomy; Tendon rupture; Acute phase
Core Tip	In this study, we demonstrate that fibro-adipogenic progenitors (FAPs) may actually attenuate early-stage degenerative processes following tendon rupture. To our knowledge, this represents the first investigation into the role of FAPs in early-stage skeletal muscle degeneration post-tendon rupture. Our work elucidates the dynamic changes in FAPs population and function during the early phases of muscle degeneration following tendon rupture, providing a more comprehensive understanding of FAPs biology in this context. These findings offer valuable insights for future research on therapeutic interventions and preventive strategies for post-rupture muscle degeneration.
Citation	Ding ZC, He JJ, Shi LZ, Qian J, Mei SH, Kang X, Chen JW. Fibro-adipogenic progenitors prevent skeletal muscle degeneration at acute phase upon tendon rupture in a murine tibialis anterior tenotomy model. World J Stem Cells 2025; In press

Received	2025-01-27 07:59
Peer-Review Started	2025-01-27 07:59
To Make the First Decision
Return for Revision	2025-02-26 08:54
Revised	2025-03-07 15:04
Second Decision	2025-06-03 03:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-10 06:36
Articles in Press	2025-06-10 06:36
Publication Fee Transferred	2025-04-02 01:24
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Typeset the Manuscript

ISSN	1948-0210 (online)
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