Publication Name	World Journal of Gastroenterology
Manuscript ID	105518
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis and inflammation in metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Antonio Liguori, Maria E Ainora, Luca Di Gialleonardo, Nicholas Viceconti, Lucrezia Petrucci, Giorgio Esposto, Maria C Giustiniani, Irene Mignini, Raffaele Borriello, Linda Galasso, Mattia Paratore, Matteo Garcovich, Laura Riccardi, Maurizio Pompili, Antonio Grieco, Antonio Gasbarrini, Luca Miele and Maria A Zocco
Funding Agency and Grant Number
Corresponding Author	Maria A Zocco, MD, PhD, Professor, CEMAD, Centro Malattie Apparato Digerente, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Gemelli 1, Rome 00168, Italy. mariaassunta.zocco@unicatt.it
Key Words	Metabolic dysfunction-associated steatotic liver disease; Multiparametric ultrasound; Liver fibrosis; Liver viscosity; Liver inflammation
Core Tip	This article provides further insights on performance of different ultrasound-based techniques for non-invasive multiparametric assessment of liver fibrosis, steatosis, and inflammation in patients with metabolic dysfunction-associated steatotic liver disease. We found that among the analyzed parameters, liver viscosity was associated with the degree of inflammation and ballooning and allows, together with ultrasound attenuation and biochemical parameters, to identify patients with metabolic dysfunction-associated steatohepatitis (MASH) with a good reliability. This could help to distinguish patients at high risk from those at low risk, and therefore it could reduce the number of liver biopsies in patients at low risk of MASH.
Citation	Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; In press

Received	2025-02-07 04:27
Peer-Review Started	2025-02-07 09:18
To Make the First Decision
Return for Revision	2025-03-13 23:26
Revised	2025-03-27 17:30
Second Decision	2025-06-10 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-10 03:17
Articles in Press	2025-06-10 03:17
Publication Fee Transferred	2025-04-03 15:11
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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