Publication Name	World Journal of Psychiatry
Manuscript ID	105751
Country	China

Category	Anatomy & Morphology
Manuscript Type	Basic Study
Article Title	Increased expression of the neuroplastin 65 protein is involved in neurofibrillary tangles and amyloid beta plaques in Alzheimer’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Ni Zheng, Yan Wang, Ling Chen, Li-Zhang Xu, Lei Zhang, Jia-Lu Wang, Juan Liu, Qi-Lei Zhang and Qiong-Lan Yuan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81771441 and No. 81371213 Natural Science Foundation of Shanghai No. 21ZR1468400
Corresponding Author	Qiong-Lan Yuan, Professor, Department of Human Anatomy, Histology and Embryology, Tongji University School of Medicine, No. 1239 Siping Road, Yangpu District, Shanghai 200092, China. yqiongl@tongji.edu.cn
Key Words	Neuroplastin 65 protein; Alzheimer’s disease; Neurofibrillary tangles; Amyloid beta; Hippocampus
Core Tip	Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, with pathological hallmarks including intracellular neurofibrillary tangles and extracellular amyloid beta (Aβ) plaques. Synaptic membrane glycoprotein neuroplastin 65 (NP65) has been previously shown to mitigate cognitive impairments and decrease Aβ plaques in the AD mouse model. However, direct evidence linking NP65 expression to AD pathology in human brain remains absent. Our present study shows that NP65 is highly expressed in a wide-range of brain areas and is significantly increased in AD cases. In addition, we found that colocalization of NP65 with neurofibrillary tangles and Aβ plaques in AD brain. Thus, our present study provides the direct evidence for NP65 involved in AD pathology.
Citation	Zheng YN, Wang Y, Chen L, Xu LZ, Zhang L, Wang JL, Liu J, Zhang QL, Yuan QL. Increased expression of the neuroplastin 65 protein is involved in neurofibrillary tangles and amyloid beta plaques in Alzheimer’s disease. World J Psychiatry 2025; In press

Received	2025-02-10 08:05
Peer-Review Started	2025-02-10 08:05
To Make the First Decision
Return for Revision	2025-03-19 07:48
Revised	2025-04-02 04:54
Second Decision	2025-04-21 13:23
Accepted by Journal Editor-in-Chief	2025-04-25 09:14
Accepted by Executive Editor-in-Chief	2025-04-27 09:07
Articles in Press	2025-04-27 09:07
Publication Fee Transferred	2025-04-07 02:44
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ISSN	2220-3206 (online)
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