Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	105872
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Integrating ultrasound and serum indicators for evaluating outcomes of targeted immunotherapy in advanced liver cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Bin Tu, Si-Yi Feng, Li-Hong Chen, Yu-Jie Huang, Ju-Zhen Zhang, Su-Yu Peng, Ding-Luan Lin and Xiao-Jian Ye
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Fujian Province 2022J011285 and 2023J011480 Fuzhou Municipal Bureau of Science and Technology Program Fund 2021-S-109 Provincial subsidy fund for health and wellness from Fujian Provincial Department of Finance BPB-2022YXJ Fujian Provincial Health Technology Project 2020GGB032
Corresponding Author	Xiao-Jian Ye, Associate Professor, Department of Ultrasound, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350001, Fujian Province, China. xjian_y@163.com
Key Words	Advanced hepatocellular carcinoma; Targeted immunotherapy; Predictive modeling; Non-invasive; Machine learning
Core Tip	Predicting treatment response in patients with advanced hepatocellular carcinoma undergoing targeted immunotherapy remains a significant challenge. This study introduced and validated the Target Immunotherapy Predictive Model, a novel, non-invasive tool that integrates pre-treatment ultrasound features (tumor diameter, changes in tumor stiffness) and accessible serum biomarkers (platelet count, white blood cell count) using machine learning. Target Immunotherapy Predictive Model outperformed traditional staging systems in predicting treatment efficacy, providing a promising solution for personalized treatment selection in advanced hepatocellular carcinoma. This approach has the potential to minimize unnecessary treatments, optimize therapeutic strategies, and ultimately improve patient outcomes. A user-friendly web calculator further enhances its clinical applicability.
Citation	<p>Tu HB, Feng SY, Chen LH, Huang YJ, Zhang JZ, Peng SY, Lin DL, Ye XJ. Integrating ultrasound and serum indicators for evaluating outcomes of targeted immunotherapy in advanced liver cancer. <i>World J Gastrointest Oncol</i> 2025; 17(5): 105872</p>

Received	2025-02-10 06:38
Peer-Review Started	2025-02-10 06:38
To Make the First Decision
Return for Revision	2025-03-19 03:31
Revised	2025-03-27 15:33
Second Decision	2025-04-17 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-17 08:21
Articles in Press	2025-04-17 08:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-04-18 03:20
Typeset the Manuscript	2025-04-27 09:02

ISSN	1948-5204 (online)
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