Publication Name	World Journal of Psychiatry
Manuscript ID	105889
Country	China

Category	Psychology, Clinical
Manuscript Type	Case Control Study
Article Title	Clinical manifestations of anxiety and depression in sepsis-associated encephalopathy and multi-omics identification of early biomarker cluster of differentiation 38
Manuscript Source	Unsolicited Manuscript
All Author List	Chun-Rong Wu, Hang-Li Zhu, Yu-Ting Sun, Shi-Hui Shen, Pei-Lin Shi, Yu-Hui Cui, Jian-Guo Tang, Chun-Hui Yang, Shang-Yuan Wang, Xiao-Li Ge and Shu-Ming Pan
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Municipal Health Commission Medical New Technology Research and Translation Seed Program No. 2024ZZ2052 Scientific Research Project funded by Shanghai Fifth People’s Hospital, Fudan University No. 2023WYRH03 Scientific Research Project funded by Shanghai Fifth People’s Hospital, Fudan University No. 2025GZRFY05 Shanghai Putuo District Health System Clinical Medicine Discipline Construction Project No. 2024tszk01 Shanghai Health System Key Discipline No. 2024ZDXK0005 Shanghai Minhang District Health and Family Planning Commission No. 2024MWDXK01
Corresponding Author	Shu-Ming Pan, PhD, Professor, Department of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China. panshuming1103@163.com
Key Words	Sepsis-associated encephalopathy; Anxiety; Depression; Cluster of differentiation 38; Metabolomics; Proteomics
Core Tip	Sepsis-associated encephalopathy (SAE) is linked to significant psychiatric symptoms, including anxiety and depression, which worsen patient outcomes. This study integrates multi-omics analysis to identify cluster of differentiation (CD) 38 as a key biomarker associated with nicotinamide adenine dinucleotide (NAD+) metabolism dysregulation in SAE. Elevated CD38 levels correlate with increased psychiatric burden and cognitive decline, suggesting its potential as an early diagnostic marker. A composite biomarker model incorporating CD38 improves SAE prediction accuracy. Targeting NAD+ metabolism may offer novel therapeutic strategies for mitigating neuropsychiatric symptoms in SAE patients. These findings emphasize the need for early psychiatric screening and metabolic interventions in SAE management.
Citation	Wu CR, Zhu HL, Sun YT, Shen SH, Shi PL, Cui YH, Tang JG, Yang CH, Wang SY, Ge XL, Pan SM. Clinical manifestations of anxiety and depression in sepsis-associated encephalopathy and multi-omics identification of early biomarker cluster of differentiation 38. World J Psychiatry 2025; In press

Received	2025-02-26 08:33
Peer-Review Started	2025-02-26 08:33
To Make the First Decision
Return for Revision	2025-03-14 06:53
Revised	2025-03-24 13:28
Second Decision	2025-04-21 13:23
Accepted by Journal Editor-in-Chief	2025-04-25 09:22
Accepted by Executive Editor-in-Chief	2025-04-27 10:11
Articles in Press	2025-04-27 10:11
Publication Fee Transferred	2025-03-26 02:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com