Publication Name	World Journal of Gastroenterology
Manuscript ID	105895
Country	China

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Retrospective Study
Article Title	Longitudinal computed tomography-based delta-radiomics of visceral adipose tissue predicts infliximab secondary loss of response in Crohn’s disease patients
Manuscript Source	Unsolicited Manuscript
All Author List	Xi Li, Fu-Long Song, Hai-Feng He, Shu-Min Zeng, Zhi-Chao Feng and Peng-Fei Rong
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 82372072 and 82071986
Corresponding Author	Peng-Fei Rong, Department of Radiology, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Changsha 410013, Hunan Province, China. rongpengfei66@163.com
Key Words	Crohn’s disease; Computed tomography enterography; Infliximab; Delta-radiomics; Secondary loss of response
Core Tip	The treatment response to infliximab in patients with Crohn's disease (CD) is heterogeneous, with approximately 23%-46% of those achieving clinical remission after induction therapy experiencing secondary loss of response (SLR) within the first year. This significantly increases the risk of serious adverse outcomes. In this study, we developed a delta-radiomics model based on longitudinal changes in visceral adipose tissue assessed through computed tomography enterography. This model further integrates clinical and imaging biomarkers to identify patients with CD at high risk of SLR. This non-invasive approach holds promise as a valuable tool for optimizing personalized treatment regimens and guiding monitoring strategies.
Citation	<p>Li X, Song FL, He HF, Zeng SM, Feng ZC, Rong PF. Longitudinal computed tomography-based delta-radiomics of visceral adipose tissue predicts infliximab secondary loss of response in Crohn’s disease patients. <i>World J Gastroenterol</i> 2025; 31(21): 105895</p>

Received	2025-02-10 05:07
Peer-Review Started	2025-02-10 05:07
To Make the First Decision
Return for Revision	2025-03-26 03:06
Revised	2025-04-05 15:45
Second Decision	2025-05-21 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-21 05:22
Articles in Press	2025-05-21 05:22
Publication Fee Transferred	2025-04-07 13:06
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-30 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
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