Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	105967
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Charged multivesicular body protein 7 was identified as a prognostic biomarker correlated with metastasis in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Rui Wei, Yi-Na Ouyang, Meng-Ting Tang, Jia-Zhen Yuan, Pei-Li Wang, Li-He Jiang and Li-Chuan Wu
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 82260715 the Middle-Aged and Young Teachers in Colleges and Universities in Guangxi Basic Ability Promotion Project 2024KY0302 Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultur-al Residues CICAR2016-P6 the Grant of research project on high-level talents of Youjiang Medical College for Nationalities YY2021SK002 Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province 202300011
Corresponding Author	Li-He Jiang, PhD, Professor, School of Basic Medical Sciences, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. jianglihe@ymun.edu.cn
Key Words	Colorectal cancer; Weighted gene co-expression network analysis; Charged multivesicular body protein 7; Metastasis biomarker; Prognosis
Core Tip	Tumor metastasis is the main reason leading to death in colorectal cancer (CRC). Unveiling CRC metastasis related biomarkers is of great significance. In this study, charged multivesicular body protein 7 (CHMP7) was identified as a prognostic factor correlated with metastasis in CRC. CHMP7 showed a lower expression in CRC patients with metastasis and CRC cell lines with high metastasis potential. The expression of CHMP7 was significantly correlated with normal, metastatic tumor, pathologic stage, and lymphatic invasion (P < 0.05). CRC patients with higher expression of CHMP7 exhibited better overall survival. Besides, Gene Set Enrichment Analysis results showed that CHMP7 might be involved in metastatic related pathways.
Citation	Wei JR, Ouyang YN, Tang MT, Yuan JZ, Wang PL, Jiang LH, Wu LC. Charged multivesicular body protein 7 was identified as a prognostic biomarker correlated with metastasis in colorectal cancer. World J Gastrointest Oncol 2025; In press

Received	2025-02-13 06:49
Peer-Review Started	2025-02-13 06:49
To Make the First Decision
Return for Revision	2025-03-12 11:09
Revised	2025-04-04 14:02
Second Decision	2025-05-20 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-20 07:03
Articles in Press	2025-05-20 07:03
Publication Fee Transferred	2025-04-14 00:59
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ISSN	1948-5204 (online)
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