Publication Name	World Journal of Psychiatry
Manuscript ID	106023
Country	China

Category	Psychiatry
Manuscript Type	Retrospective Study
Article Title	Permissive hypercapnia combined with goal-directed fluid therapy improve postoperative mental health in elderly patients undergoing laparoscopic surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Li Yuan, Xiao-Min Zhang, Na Liu, Jun-Qi Shi, Xiao-Jie Sun, Guo-Li Li and Jin-Liang Teng
Funding Agency and Grant Number	Funding Agency Grant Number 2024 Hebei Medical Science Research Project No. 20241638 Key Research and Development Program of Zhangjiakou City No. 2311041D
Corresponding Author	Jin-Liang Teng, Chief Physician, MD, Department of Anesthesiology, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Qiaoxi District, Zhangjiakou 075000, Hebei Province, China. tengjinliang@126.com
Key Words	Permissive hypercapnia; Goal-directed fluid therapy; Laparoscopic surgery; Elderly patients; Enhanced recovery; Anxiety and depression
Core Tip	This study highlights the benefits of permissive hypercapnia (PH) combined with goal-directed fluid therapy (GDFT) in elderly patients undergoing laparoscopic surgery. The PH + GDFT strategy is demonstrated to significantly accelerate postoperative recovery, reduce complications, and alleviate anxiety and depression. Additionally, it is observed to reduce levels of inflammatory markers, enhance sleep quality, and improve overall patient satisfaction. Multivariate analysis confirms PH + GDFT as an independent protective factor against postoperative psychological distress. These findings advocate for the integration of PH and GDFT into perioperative management to optimize both physical and psychological outcomes, particularly for elderly patients. This study offers clinical evidence supporting the refinement of anesthesia and fluid management strategies in minimally invasive surgery.
Citation	Yuan L, Zhang XM, Liu N, Shi JQ, Sun XJ, Li GL, Teng JL. Permissive hypercapnia combined with goal-directed fluid therapy improve postoperative mental health in elderly patients undergoing laparoscopic surgery. World J Psychiatry 2025; In press

Received	2025-03-07 08:09
Peer-Review Started	2025-03-07 08:09
To Make the First Decision
Return for Revision	2025-03-28 08:33
Revised	2025-04-19 13:43
Second Decision	2025-06-10 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-10 09:11
Articles in Press	2025-06-10 09:11
Publication Fee Transferred	2025-04-27 06:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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