Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	106080
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation via cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Tao Wang, Yu-Le Yong, Ze-Kun Liu, Yi-Xuan Shen, Xiang-Min Yang and Zhi-Nan Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82002940 and No. 82203336 Shaanxi Natural Science Foundation No. 2023-JC-YB-166
Corresponding Author	Zhi-Nan Chen, PhD, Professor, Department of Cell Biology, National Translational Science Center for Molecular Medicine, The Fourth Military Medical University, No. 169 Changle West Road, Xi’an 710032, Shaanxi Province, China. znchen@fmmu.edu.cn
Key Words	Hepatocellular carcinoma; Regulator of chromosome condensation 1; Proliferation; Cell cycle; Cell division cycle-associated 8; Phosphoinositide 3-kinase/protein kinase B pathway
Core Tip	In this study, we investigated the role of regulator of chromosome condensation 1 (RCC1) in promoting the proliferation of hepatocellular carcinoma (HCC) cells. Initially, we determined that RCC1 is significantly upregulated in HCC and correlates with poor prognosis. Subsequently, we demonstrated that RCC1 facilitates the G1/S phase transition by regulating cell division cycle-associated 8. Furthermore, our findings indicate that the RCC1/cycle-associated 8 axis promotes HCC proliferation via the phosphoinositide 3-kinase/protein kinase B/cyclin-dependent kinase inhibitor 1a signaling pathway. Collectively, this research elucidates the association between RCC1 and HCC and highlights the role of RCC1 in regulating the G1/S transition of the cell cycle.
Citation	Wang YT, Yong YL, Liu ZK, Shen YX, Yang XM, Chen ZN. Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation via cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling. World J Gastrointest Oncol 2025; In press

Received	2025-02-17 08:49
Peer-Review Started	2025-02-17 08:49
To Make the First Decision
Return for Revision	2025-03-11 07:17
Revised	2025-04-01 03:55
Second Decision	2025-04-18 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-18 07:26
Articles in Press	2025-04-18 07:26
Publication Fee Transferred	2025-04-02 13:08
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Typeset the Manuscript

ISSN	1948-5204 (online)
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