Publication Name	World Journal of Cardiology
Manuscript ID	106123
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Systematic Reviews
Article Title	Circulating microRNAs in predicting fibrosis in hypertrophic cardiomyopathy: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Maneeth Mylavarapu, Lakshmi Sai Meghana Kodali, Roopeessh Vempati, Jai Sivanandan Nagarajan, Ankit Vyas and Rupak Desai
Funding Agency and Grant Number
Corresponding Author	Rupak Desai, Senior Researcher, Outcomes Research, Independent Researcher, Scottdale, Atlanta, GA 30079, United States. drrupakdesai@gmail.com
Key Words	Circulating micro RNAs; Hypertrophic cardiomyopathy; Myocardial fibrosis; Cardiac magnetic resonance; Late gadolinium enhancement; Systematic Review
Core Tip	Circulating microRNAs (miRNA) show promise as non-invasive biomarkers for myocardial fibrosis in hypertrophic cardiomyopathy (HCM). Our systematic review of eight studies identified miRNAs miR-21, miR-29a, and miR-221 as frequently dysregulated, with elevated miR-21 and miR-29a correlating with increased fibrosis detected by cardiac magnetic resonance imaging. These findings suggest that miRNAs could be a less invasive approach to the detection of fibrosis in HCM. However, the clinical validation of these findings has to be further validated with further research.
Citation	Mylavarapu M, Kodali LSM, Vempati R, Nagarajan JS, Vyas A, Desai R. Circulating microRNAs in predicting fibrosis in hypertrophic cardiomyopathy: A systematic review. World J Cardiol 2025; In press

Received	2025-02-17 03:19
Peer-Review Started	2025-02-17 03:20
To Make the First Decision
Return for Revision	2025-04-02 11:18
Revised	2025-04-06 05:08
Second Decision	2025-04-28 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-28 08:15
Articles in Press	2025-04-28 08:15
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ISSN	1949-8462 (online)
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