Publication Name	World Journal of Orthopedics
Manuscript ID	106145
Country	United States

Category	Orthopedics
Manuscript Type	Meta-Analysis
Article Title	Role of neutrophil to lymphocyte ratio in osteoarthritis: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Maryam Salimi, Shokoufeh Khanzadeh, Brandon Lucke-Wold, Arshin Ghaedi and Austin V Stone
Funding Agency and Grant Number
Corresponding Author	Austin V Stone, Associate Professor, MD, PhD, Department of Orthopaedic Surgery and Sports Medicine, University of Kentucky, Suite K401, 740 S Limestone, Lexington, KY 40536, United States. austin.stone@uky.edu
Key Words	Neutrophil to lymphocyte ratio; Osteoarthritis; Meta-analysis; Inflammatory biomarker; Systemic inflammation
Core Tip	This systematic review and meta-analysis evaluate the role of the neutrophil-to-lymphocyte ratio (NLR) in osteoarthritis (OA). Our findings indicate that OA patients have significantly higher NLR levels than healthy controls, suggesting its potential as an inflammatory biomarker. However, NLR does not significantly correlate with OA severity or study design, limiting its utility in assessing disease progression. Further research is needed to clarify NLR’s clinical relevance in OA diagnosis and management.
Citation	<p>Salimi M, Khanzadeh S, Lucke-Wold B, Ghaedi A, Stone AV. Role of neutrophil to lymphocyte ratio in osteoarthritis: A systematic review and meta-analysis. <i>World J Orthop</i> 2025; 16(5): 106145</p>

Received	2025-02-19 09:55
Peer-Review Started	2025-02-19 09:55
To Make the First Decision
Return for Revision	2025-03-21 07:06
Revised	2025-03-25 22:54
Second Decision	2025-04-17 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-17 09:08
Articles in Press	2025-04-17 09:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-05 10:12

ISSN	2218-5836 (online)
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