Publication Name	World Journal of Cardiology
Manuscript ID	106147
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Metabolic-dysfunction associated steatotic liver disease and atrial fibrillation: A review of pathogenesis
Manuscript Source	Invited Manuscript
All Author List	Inderjeet Singh Bharaj, Ajit Singh Brar, Jasraj Kahlon, Anmol Singh, Priya Hotwani, Vikash Kumar, Aalam Sohal and Akash Batta
Funding Agency and Grant Number
Corresponding Author	Aalam Sohal, MD, Department of Gastroenterology and Hepatology, Creighton University School of Medicine, 3216 NE 45th Pl Suite 212, Phoenix, AZ 85012, United States. aalamsohal@gmail.com
Key Words	Metabolic-dysfunction associated steatotic liver disease; Non-alcoholic fatty liver disease; Atrial fibrillation; Non-alcoholic steatohepatitis; Insulin resistance; Oxidative stress; Dyslipidemia; Obesity
Core Tip	Metabolic dysfunction-associated steatotic liver disease (MASLD) and atrial fibrillation (AF) share common metabolic risk factors, including obesity, diabetes, dyslipidemia, and hypertension. Pathophysiological mechanisms such as systemic inflammation, oxidative stress, insulin resistance, and renin-angiotensin-aldosterone system activation link MASLD to AF. Chronic inflammation and oxidative stress in MASLD lead to atrial remodeling, creating an arrhythmogenic substrate. Effective management of MASLD requires targeted risk-factor modification strategies and a multidisciplinary approach to reduce cardiovascular risk and prevent arrhythmias. Early detection and comprehensive management are crucial to mitigate the dual burden of MASLD and AF.
Citation	Bharaj IS, Brar AS, Kahlon J, Singh A, Hotwani P, Kumar V, Sohal A, Batta A. Metabolic-dysfunction associated steatotic liver disease and atrial fibrillation: A review of pathogenesis. World J Cardiol 2025; In press

Received	2025-02-17 07:00
Peer-Review Started	2025-02-17 07:01
To Make the First Decision
Return for Revision	2025-03-26 04:21
Revised	2025-04-09 01:41
Second Decision	2025-05-19 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-21 13:49
Articles in Press	2025-05-21 13:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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