Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	106161
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Tumor-derived exosomal miR-425-5p and miR-135b-3p enhance colorectal cancer progression through immune suppression and vascular permeability promotion
Manuscript Source	Unsolicited Manuscript
All Author List	Chun-Zai Feng, Si-Quan Zhong, Shao-Wei Ye, Zheng Zheng, Hao Sun and Shi-Hai Zhou
Funding Agency and Grant Number
Corresponding Author	Shi-Hai Zhou, Associate Chief Physician, Department of Tumor Surgery, Zhongshan City People’s Hospital, No. 2 Sunwen East Road, Shiqi District, Zhongshan 528403, Guangdong Province, China. 13068120688@163.com
Key Words	Colorectal cancer; Exosomes; MiR-425-5p; MiR-135b-3p; Immune modulation; Vascular permeability
Core Tip	This study identifies exosomal miR-425-5p and miR-135b-3p as critical regulators of colorectal cancer (CRC) progression. These microRNAs (miRNAs) are significantly upregulated in CRC-derived exosomes and modulate the tumor microenvironment through distinct mechanisms. MiR-425-5p promotes immune suppression by inducing macrophage M2 polarization and skewing T cell differentiation toward pro-tumor subsets, while miR-135b-3p enhances vascular permeability and angiogenesis. Inhibition of these miRNAs in preclinical models significantly reduces tumor growth and metastasis, suggesting they represent promising therapeutic targets for CRC. The findings provide novel insights into exosomal miRNA-mediated immune modulation and vascular remodeling in CRC progression.
Citation	Feng CZ, Zhong SQ, Ye SW, Zheng Z, Sun H, Zhou SH. Tumor-derived exosomal miR-425-5p and miR-135b-3p enhance colorectal cancer progression through immune suppression and vascular permeability promotion. World J Gastrointest Oncol 2025; In press

Received	2025-02-19 09:54
Peer-Review Started	2025-02-19 09:54
To Make the First Decision
Return for Revision	2025-03-11 07:33
Revised	2025-03-24 03:40
Second Decision	2025-04-22 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-22 07:44
Articles in Press	2025-04-22 07:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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