Publication Name	World Journal of Orthopedics
Manuscript ID	106183
Country	China

Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Long non-coding RNA GAS5 promotes neuronal apoptosis in spinal cord injury via the miR-21/PTEN axis
Manuscript Source	Unsolicited Manuscript
All Author List	Ying-Jie Wang, Zhong-Zheng Zhi, Tao Liu, Jian Kang and Guang-Hui Xu
Funding Agency and Grant Number	Funding Agency Grant Number The Major Research plan from the Health Commission of Hongkou District, ShangHai, China 2001-03 Academic subject boosting plan in the Shanghai Fourth People’s Hospital affiliated to Tongji University School of Medicine, Shanghai, China SY-XKZT-2020-1003
Corresponding Author	Jian Kang, MD, Department of Spine Surgery, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Department of Orthopedics Shanghai Fourth People's Hospital School of Medicine, Tongji University Shanghai, PR China, Shanghai 200434, China. kangjian_spine@126.com
Key Words	Spinal cord injury; Long non-coding RNA; Growth arrest-specific transcript 5; MicroRNA-21; Neuronal apoptosis
Core Tip	This study investigates the role of long non-coding RNA growth arrest-specific transcript 5 (GAS5) in spinal cord injury (SCI)-induced neuronal apoptosis. We demonstrate that GAS5 acts as a molecular sponge to bind miR-21, thereby upregulating PTEN expression and inhibiting the AKT signaling pathway, ultimately promoting neuronal apoptosis. Inhibiting GAS5 expression alleviates neuronal apoptosis and improves motor function recovery in SCI rat models, suggesting that targeting GAS5 may be a promising therapeutic strategy for SCI.
Citation	<p>Wang YJ, Zhi ZZ, Liu T, Kang J, Xu GH. Long non-coding RNA GAS5 promotes neuronal apoptosis in spinal cord injury via the miR-21/PTEN axis. <i>World J Orthop</i> 2025; 16(5): 106183</p>

Received	2025-02-19 09:38
Peer-Review Started	2025-02-19 09:39
To Make the First Decision
Return for Revision	2025-03-05 11:48
Revised	2025-03-18 08:30
Second Decision	2025-04-17 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-17 09:11
Articles in Press	2025-04-17 09:11
Publication Fee Transferred	2025-03-25 07:58
Edit the Manuscript by Language Editor	2025-04-27 06:26
Typeset the Manuscript	2025-05-08 01:08

ISSN	2218-5836 (online)
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