Publication Name	World Journal of Stem Cells
Manuscript ID	106194
Country	India

Category	Psychiatry
Manuscript Type	Evidence Review
Article Title	Childhood insulin resistance and neural stem cell dysfunction in psychiatric disorders: Role of de novo lipogenesis and treatment perspectives
Manuscript Source	Invited Manuscript
All Author List	Mohammad M Khan, Zaw Ali Khan, Mohsin Ali Khan and Gauri Pandey
Funding Agency and Grant Number
Corresponding Author	Mohammad M Khan, PhD, Professor, Laboratory of Translational Neurology and Molecular Psychiatry, Department of Biotechnology, Era’s Lucknow Medical College and Hospital, and Faculty of Science, Era University, Sarfarazganj, Hardoi Road, Lucknow 226003, Uttar Pradesh, India. mmkhan0@gmail.com
Key Words	Childhood insulin resistance; Neural stem cell dysfunction; De novo lipogenesis; Psychiatric disorders; Anti-inflammatory agents; Stem cell therapy
Core Tip	Childhood insulin resistance (IR) is a potential risk factor for developing psychiatric disorders (PDs). Although insulin regulates neural stem cell (NSC) proliferation and function, IR is associated with impaired NSC proliferation and cognitive dysfunction, which are prominent features of PDs. While the mechanisms underlying IR and NSC dysfunction in PDs remain unclear, intracellular lipids/fatty acids synthesized via de novo lipogenesis could be the primary mediators. Since psychotropic drugs further deteriorate IR and stimulate de novo lipogenesis, prospects of various adjunctive therapies, especially stem cell therapy, in treating IR in schizophrenia and depression are discussed.
Citation	Khan MM, Khan ZA, Khan MA, Pandey G. Childhood insulin resistance and neural stem cell dysfunction in psychiatric disorders: Role of de novo lipogenesis and treatment perspectives. World J Stem Cells 2025; In press

Received	2025-02-19 13:08
Peer-Review Started	2025-02-21 00:14
To Make the First Decision
Return for Revision	2025-03-19 08:56
Revised	2025-04-20 09:25
Second Decision	2025-06-18 05:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-25 07:12
Articles in Press	2025-06-25 07:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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