Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	106208
Country	China

Category	Medicine, General & Internal
Manuscript Type	Case Report
Article Title	Refractory chronic diarrhea complicated with optic neuritis in a young woman: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Chao-Nan Chen, Xin-Yu Fan, Chong-Mei Yang, Xiao-Hua Zhang and Jin Liu
Funding Agency and Grant Number
Corresponding Author	Jin Liu, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Jinan 250000, Shandong Province, China. miracle713@163.com
Key Words	Collagenous sprue; Chronic diarrhea; Optic neuritis; Glucocorticoid dependence; Malabsorption; Case report
Core Tip	Collagenous sprue is a rare and unrecognized cause of diarrhea and weight loss and affects mainly the duodenum and small bowel. The clinical picture often resembles that of coeliac sprue, the main differential diagnosis, albeit refractory to a gluten-free diet. The histological features are fundamentally characterized by the deposition of collagen beneath the basement membrane of the gut mucosa. Treatment should be initiated as soon as the diagnosis is established to prevent the progression of fibrosis. We describe the case of a 34-year-old woman with a collagenous sprue, her diagnostic workup, histopathological examination, and response to treatment. This case can inform future clinicians to aid in timely and correct diagnosis.
Citation	Chen CN, Fan XY, Yang CM, Zhang XH, Liu J. Refractory chronic diarrhea complicated with optic neuritis in a young woman: A case report. World J Gastrointest Endosc 2025; In press

Received	2025-02-19 15:35
Peer-Review Started	2025-02-19 15:35
To Make the First Decision
Return for Revision	2025-03-23 03:43
Revised	2025-04-06 03:13
Second Decision	2025-05-20 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-20 08:47
Articles in Press	2025-05-20 08:47
Publication Fee Transferred	2025-04-22 15:19
Edit the Manuscript by Language Editor	2025-05-27 16:26
Typeset the Manuscript

ISSN	1948-5190 (online)
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