Publication Name	World Journal of Hepatology
Manuscript ID	106291
Country	Chile

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Heart rate variability in the clinical assessment of patients with chronic liver disease
Manuscript Source	Invited Manuscript
All Author List	Nicolás Bustos, Flavia Giubergia, Cristóbal Mora, Christian Lara, Álvaro Urzúa, Máximo Cattaneo, Jaime Poniachik, Daniela B Vera and Abraham IJ Gajardo
Funding Agency and Grant Number	Funding Agency Grant Number National Agency of Research and Development (ANID), Government of Chile Initiation in Research FONDECYT grant 11241548
Corresponding Author	Abraham IJ Gajardo, MD, PhD, Professor, Program of Pathophysiology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile, Santiago 8380453, Chile. aij.gajardo@gmail.com
Key Words	Chronic liver disease; Autonomic nervous system; Heart rate variability; Autonomic dysfunction; Complications of liver cirrhosis; Liver transplant
Core Tip	Autonomic dysfunction (AD) is common in cirrhotic patients and is linked to poor outcomes. Heart rate variability (HRV), a noninvasive measure of autonomic balance, could be useful in managing chronic liver disease (CLD) patients. This article explores AD mechanisms, HRV assessment, and its diagnostic, prognostic, and therapeutic relevance in CLD, including liver transplantation.
Citation	Bustos N, Giubergia F, Mora C, Lara C, Urzúa Á, Cattaneo M, Poniachik J, Vera DB, Gajardo AIJ. Heart rate variability in the clinical assessment of patients with chronic liver disease. World J Hepatol 2025; In press

Received	2025-02-21 03:17
Peer-Review Started	2025-02-21 03:17
To Make the First Decision
Return for Revision	2025-03-26 15:50
Revised	2025-04-10 00:59
Second Decision	2025-06-10 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-10 10:07
Articles in Press	2025-06-10 10:07
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ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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