Publication Name	Artificial Intelligence in Cancer
Manuscript ID	106356
Country	China

Category	Computer Science, Artificial Intelligence
Manuscript Type	Retrospective Study
Article Title	Can ChatGPT and DeepSeek help cancer patients: A comparative study of artificial intelligence models in clinical decision support
Manuscript Source	Invited Manuscript
All Author List	Meng Sun, Jun Yu, Jing-Wen Zhou, Ming Ye, Fang Ye and Mei Ding
Funding Agency and Grant Number	Funding Agency Grant Number Jiangsu Provincial Key R&D Program No. BE2019723 China Academy of Chinese Medical Sciences No. CI2022E028XB
Corresponding Author	Fang Ye, . 1596837403@qq.com
Key Words	Artificial intelligence; Clinical decision support; Oncology; ChatGPT; DeepSeek; Precision medicine
Core Tip	This study compares the efficacy of ChatGPT [a general-purpose artificial intelligence (AI)] and DeepSeek (a domain-specific clinical AI) in oncology decision support. DeepSeek demonstrated superior diagnostic accuracy (F1-score: 89.2% vs 76.5%) and guideline adherence (Cohen’s κ: 0.82 vs 0.67), while ChatGPT excelled in patient communication (readability score: 8.2/10 vs 6.5/10). Both models underperformed in rare cancer subtypes (F1 < 60%), highlighting the need for hybrid systems integrating technical precision and patient-centered communication. This work advocates for AI models tailored to oncology’s heterogeneous demands, with dynamic updates to address evolving clinical guidelines and rare malignancies.
Citation	Sun M, Yu J, Zhou JW, Ye M, Ye F, Ding M. Can ChatGPT and DeepSeek help cancer patients: A comparative study of artificial intelligence models in clinical decision support. Artif Intell Cancer 2025; In press

Received	2025-02-24 10:59
Peer-Review Started	2025-02-24 10:59
To Make the First Decision
Return for Revision	2025-04-02 11:22
Revised	2025-04-02 13:27
Second Decision	2025-04-27 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-27 08:41
Articles in Press	2025-04-27 08:41
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ISSN	2644-3228 (online)
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