Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	106393
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Analysis of serum S100A12, soluble advanced glycation end products receptor, and gut microbiome in elderly colorectal cancer patients
Manuscript Source	Unsolicited Manuscript
All Author List	Shuai-Bo Qiao, Ming-Liao Niu, Wei-Tao Liang, Long-Jiang Zhang, Xiang Chen and Ying-Kun Zhu
Funding Agency and Grant Number
Corresponding Author	Long-Jiang Zhang, Chief Physician, Department of Anorectal Surgery, Henan Province Hospital of Traditional Chinese Medicine, No. 6 Dongfeng Road, Zhengzhou 450000, Henan Province, China. hnszyyzlj@163.com
Key Words	Predictive value; Chemotherapy efficacy; Correlation; Gut microbiome dysbiosis; Soluble receptor for advanced glycation end products; Serum S100 calcium-binding protein A12; Colorectal cancer; Elderly
Core Tip	Elevated serum S100 calcium-binding protein A12 and soluble receptor for advanced glycation end products in elderly colorectal cancer patients reflect gut microbiome dysbiosis and systemic inflammation, driven by interleukin-6/tumor necrosis factor-α signaling. Their post-chemotherapy decline parallels microbiota restoration, supporting a microbiome-inflammation-biomarker axis. The combined biomarker model offers robust clinical utility for chemotherapy efficacy prediction and personalized therapeutic strategies.
Citation	Qiao SB, Niu ML, Liang WT, Zhang LJ, Chen X, Zhu YK. Analysis of serum S100A12, soluble advanced glycation end products receptor, and gut microbiome in elderly colorectal cancer patients. World J Gastrointest Oncol 2025; In press

Received	2025-03-12 08:56
Peer-Review Started	2025-03-12 08:57
To Make the First Decision
Return for Revision	2025-04-02 09:23
Revised	2025-04-03 12:33
Second Decision	2025-04-25 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-25 05:58
Articles in Press	2025-04-25 05:58
Publication Fee Transferred	2025-04-09 06:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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