Publication Name	World Journal of Diabetes
Manuscript ID	106470
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Clinical Trials Study
Article Title	Factors influencing insulin requirements in using continuous subcutaneous insulin infusion or multiple daily injections in type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Ruo-Man Sun, De-Xing Dai, Feng Xu, Ya-Li Ling and Zhong-Jian Xie
Funding Agency and Grant Number	Funding Agency Grant Number National Key R and D Program of China No. 2021YFC2501700 National Key R and D Program of China No. 2021YFC2501705 National Natural Science Foundation of China No. 82171580 National Natural Science Foundation of China No. 81672646
Corresponding Author	Zhong-Jian Xie, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Disease, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha 410011, Hunan Province, China. zhongjian.xie@csu.edu.cn
Key Words	Continuous subcutaneous insulin infusion; Insulin dose; Multiple daily injections; Type 2 diabetes; Glycemic control
Core Tip	This study demonstrates that patients with type 2 diabetes mellitus (T2DM) on continuous subcutaneous insulin infusion require a lower dose of insulin than those receiving multiple daily injections, while achieving good glycemic control. Fasting plasma glucose, glycated hemoglobin, body mass index, and waist circumference correlated with increased insulin requirements across both therapies. Our data also suggest that the ratio of total basal insulin dose to total daily dose of approximately 40% (lower than the 50% recommended percentage) may optimize glycemic outcomes. These findings highlight the need for careful selection of insulin therapy and revision of basal insulin recommendations in T2DM management.
Citation	Sun RM, Dai DX, Xu F, Ling YL, Xie ZJ. Factors influencing insulin requirements in using continuous subcutaneous insulin infusion or multiple daily injections in type 2 diabetes. World J Diabetes 2025; In press

Received	2025-02-27 11:47
Peer-Review Started	2025-03-03 00:10
To Make the First Decision
Return for Revision	2025-04-08 07:06
Revised	2025-04-20 16:21
Second Decision	2025-05-27 10:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-09 09:36
Articles in Press	2025-06-09 09:36
Publication Fee Transferred	2025-04-21 13:55
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Typeset the Manuscript

ISSN	1948-9358 (online)
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