Publication Name	World Journal of Gastroenterology
Manuscript ID	106538
Country	Russia

Category	Biochemistry & Molecular Biology
Manuscript Type	Letter to the Editor
Article Title	Application of Wuling powder in the treatment of ulcerative colitis complicated by depression as a new therapy principle
Manuscript Source	Unsolicited Manuscript
All Author List	Olga V Smirnova, Aleksander Sinyakov and Edward V Kasparov
Funding Agency and Grant Number
Corresponding Author	Olga V Smirnova, MD, PhD, Professor, Laboratory of Clinical Pathophysiology, Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”, Separate Subdivision Research Institute for Medical Problems of the North, Partizana Zheleznyaka St 3G, Krasnoyarsk 660022, Russia. ovsmirnova71@mail.ru
Key Words	Ulcerative colitis; Depression; Signaling pathways; Precursor of brain-derived neurotrophic factor/p75 neurotrophin receptor/sortilin; Brain-derived neurotrophic factor/tropomyosin receptor kinase B; Wuling powder
Core Tip	The article focuses on the feasibility of using Wuling powder, which modulates the precursor of brain-derived neurotrophic factor/p75 neurotrophin receptor/sortilin and brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling pathways, in the treatment of ulcerative colitis complicated by depression. This problem is highlighted in the article by Wang et al, where they demonstrate that application of the traditional Chinese medicine Wuling normalizes the signaling pathways in the nervous tissue, reduces manifestations of depression and intestinal inflammation in patients with ulcerative colitis. This study is notable for an extremely promising and strategically new objective and a very impressive methodological level of research.
Citation	Smirnova OV, Sinyakov A, Kasparov EV. Application of Wuling powder in the treatment of ulcerative colitis complicated by depression as a new therapy principle. World J Gastroenterol 2025; In press

Received	2025-03-03 14:20
Peer-Review Started	2025-03-03 14:20
To Make the First Decision
Return for Revision	2025-03-25 02:17
Revised	2025-04-04 03:14
Second Decision	2025-04-27 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-27 05:27
Articles in Press	2025-04-27 05:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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